Evaluation of the dentate gyrus in adult mice exposed to acetaminophen (paracetamol) on postnatal day 10.,International Journal of Developmental Neuroscience

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Evaluation of the dentate gyrus in adult mice exposed to acetaminophen (paracetamol) on postnatal day 10.
International Journal of Developmental Neuroscience ( IF 1.7 ) Pub Date : 2021-01-12 , DOI: 10.1002/jdn.10079
Gaëtan Philippot ₁ , Sofie V Hellsten ₁ , Henrik Viberg ₂ , Robert Fredriksson ₁

Affiliation

Acetaminophen (AAP; or paracetamol) is a widely used nonprescription drug with antipyretic and analgesic properties. Alarmingly, there is an increasing body of evidence showing that developmental exposure to AAP is associated with adverse behavioral outcomes later in life. We have previously shown that relevant doses of AAP into ten-day-old mice affected memory, learning and locomotor activity in the adult animals. Interestingly, the neurons of the dentate gyrus (DG) have a relatively late time of origin as they are generated during the first two weeks of postnatal life in rodents. Since the generation of these cells, which are important for memory processing, coincides with our AAP exposure, we aim to investigate if the cytoarchitecture of the DG is affected by postnatal day 10 AAP treatment. In addition, we investigate if markers for differentiation and migration in the hippocampus were affected by the same treatment. We did not observe any visual effects in adult DG cytoarchitecture, nor any changes of markers for differentiation/migration in the hippocampus in 24 h after exposure. Even though a large effect size was estimated on adult DG thickness following AAP exposure, the estimated 95% CIs around the differences of the means reveal no significant effect. Hence, larger sample sizes are warranted to clarify if neonatal AAP exposure affect adult DG thickness in mice.

中文翻译：

对出生后第 10 天暴露于对乙酰氨基酚（扑热息痛）的成年小鼠齿状回的评估。

对乙酰氨基酚（AAP；或扑热息痛）是一种广泛使用的非处方药，具有解热和镇痛作用。令人担忧的是，越来越多的证据表明，AAP 的发育暴露与晚年的不良行为结果有关。我们之前已经表明，将相关剂量的 AAP 注入 10 天大的小鼠会影响成年动物的记忆、学习和运动活动。有趣的是，齿状回 (DG) 的神经元的起源时间相对较晚，因为它们是在啮齿动物出生后的前两周内产生的。由于这些对记忆处理很重要的细胞的产生与我们的 AAP 暴露同时发生，我们的目标是调查 DG 的细胞结构是否受到出生后第 10 天 AAP 治疗的影响。此外，我们调查了海马体中分化和迁移的标志物是否受到相同处理的影响。我们没有观察到成人 DG 细胞结构的任何视觉效果，也没有观察到暴露后 24 小时海马中分化/迁移标记的任何变化。尽管在 AAP 暴露后估计对成人 DG 厚度有很大的影响，但围绕平均值差异的估计 95% CI 显示没有显着影响。因此，需要更大的样本量来阐明新生儿 AAP 暴露是否会影响小鼠的成年 DG 厚度。尽管在 AAP 暴露后估计对成人 DG 厚度有很大的影响，但围绕平均值差异的估计 95% CI 显示没有显着影响。因此，需要更大的样本量来阐明新生儿 AAP 暴露是否会影响小鼠的成年 DG 厚度。尽管在 AAP 暴露后估计对成人 DG 厚度有很大的影响，但围绕平均值差异的估计 95% CI 显示没有显着影响。因此，需要更大的样本量来阐明新生儿 AAP 暴露是否会影响小鼠的成年 DG 厚度。

更新日期：2021-01-12

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