Tumor cell invasiveness in the initial stages of bladder cancer development ‐ A computational study,International Journal for Numerical Methods in Biomedical Engineering

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Tumor cell invasiveness in the initial stages of bladder cancer development ‐ A computational study
International Journal for Numerical Methods in Biomedical Engineering ( IF 2.2 ) Pub Date : 2020-11-22 , DOI: 10.1002/cnm.3417
Joao Carvalho ₁ , Valeria Lopes ₁ , Rui Travasso ₁

Affiliation

Bladder cancer is one of the most common types of cancer, being the sixth more frequent in men, and one with higher recurrence rates and overall treatment costs. We introduce an agent‐based computational model of the urothelium, adopting a Cellular Potts Model (CPM) approach to describe both a healthy urothelium and the development of bladder cancer. We focus on the identification of the conditions in which cancer cells cross, by mechanical means, the basement membrane and invade the bladder lamina propria. When within the urothelium the tumor grows in a very constrained environment. These tight conditions imply that the urothelium layer where the tumor initiates greatly determines tumor growth and invasiveness. Moreover, we demonstrate how specific mechanical properties of the cancer cells, as their stiffness or the adhesion to neighboring cells, heavily modulate the critical initial moments of tumor development. We propose that these characteristics should be considered as therapeutic targets to control tumor growth.

中文翻译：

膀胱癌发展初期的肿瘤细胞侵袭性 - 一项计算研究

膀胱癌是最常见的癌症类型之一，在男性中排名第六，并且复发率和总体治疗费用更高。我们引入了基于代理的尿路上皮计算模型，采用细胞 Potts 模型 (CPM) 方法来描述健康的尿路上皮和膀胱癌的发展。我们专注于确定癌细胞通过机械方式穿过基底膜并侵入膀胱固有层的条件。当在尿路上皮内时，肿瘤在非常受限的环境中生长。这些严密的条件意味着肿瘤起始的尿路上皮层在很大程度上决定了肿瘤的生长和侵袭性。此外，我们展示了癌细胞的特定机械特性，如它们的刚度或与相邻细胞的粘附，严重调节肿瘤发展的关键初始时刻。我们建议应将这些特征视为控制肿瘤生长的治疗靶点。

更新日期：2021-01-18

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