Parahippocampal area three gray matter is reduced in first‐episode schizophrenia spectrum: Discovery and replication samples,Human Brain Mapping

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Parahippocampal area three gray matter is reduced in first‐episode schizophrenia spectrum: Discovery and replication samples
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-11-21 , DOI: 10.1002/hbm.25256
Mark T Curtis ₁ , Brian A Coffman ₁ , Dean F Salisbury ₁

Affiliation

Early course schizophrenia is associated with reduced gray matter. The specific structures affected first and how deficits impact symptoms and cognition remain unresolved. We used the Human Connectome Project multimodal parcellation (HCP‐MMP) to precisely identify cortical areas and investigate thickness abnormalities in discovery and replication samples of first‐episode schizophrenia spectrum individuals (FESz). In the discovery sample, T1w scans were acquired from 31 FESz and 31 matched healthy controls (HC). Thickness was calculated for 360 regions in Freesurfer. In the replication sample, high‐resolution T1w, T2w, and BOLD‐rest scans were acquired from 23 FESz and 32 HC and processed with HCP protocols. Thickness was calculated for regions significant in the discovery sample. After FDR correction (q < .05), left and right parahippocampal area 3 (PHA3) were significantly thinner in FESz. In the replication sample, bilateral PHA3 were again thinner in FESz (q < .05). Exploratory correlation analyses revealed left PHA3 was positively associated with hallucinations and right PHA3 was positively associated with processing speed, working memory, and verbal learning. The novel use of the HCP‐MMP in two independent FESz samples revealed thinner bilateral PHA3, suggesting this byway between cortical and limbic processing is a critical site of pathology near the emergence of psychosis.

中文翻译：

首发精神分裂症谱系海马旁区三灰质减少：发现和复制样本

早期精神分裂症与灰质减少有关。首先受影响的特定结构以及缺陷如何影响症状和认知仍未解决。我们使用人类连接组计划多模式分割 (HCP-MMP) 来精确识别皮质区域并调查首发精神分裂症谱系个体 (FESz) 的发现和复制样本中的厚度异常。在发现样本中，T1w 扫描来自 31 个 FESz 和 31 个匹配的健康对照 (HC)。在 Freesurfer 中计算了 360 个区域的厚度。在复制样本中，从 23 FESz 和 32 HC 中获取高分辨率 T1w、T2w 和 BOLD-rest 扫描，并使用 HCP 协议进行处理。厚度是为发现样本中的重要区域计算的。FDR 校正后 ( q< .05)，FESz 中左右海马旁区 3 (PHA3) 明显变薄。在复制样本中，双侧 PHA3 在 FESz 中再次变薄 ( q < .05)。探索性相关分析显示，左侧 PHA3 与幻觉呈正相关，右侧 PHA3 与处理速度、工作记忆和语言学习呈正相关。HCP-MMP 在两个独立的 FESz 样本中的新用途揭示了更薄的双侧 PHA3，表明皮质和边缘处理之间的这条通路是精神病出现附近病理学的关键部位。

更新日期：2021-01-19

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