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The heritability of insomnia: A meta‐analysis of twin studies
Genes, Brain and Behavior ( IF 2.4 ) Pub Date : 2020-11-21 , DOI: 10.1111/gbb.12717 Nicola L Barclay 1 , Desi Kocevska 2 , Wichor M Bramer 3 , Eus J W Van Someren 2, 4 , Philip Gehrman 5
Genes, Brain and Behavior ( IF 2.4 ) Pub Date : 2020-11-21 , DOI: 10.1111/gbb.12717 Nicola L Barclay 1 , Desi Kocevska 2 , Wichor M Bramer 3 , Eus J W Van Someren 2, 4 , Philip Gehrman 5
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Twin studies of insomnia exhibit heterogeneity in estimates of heritability. This heterogeneity is likely because of sex differences, age of the sample, the reporter and the definition of insomnia. The aim of the present study was to systematically search the literature for twin studies investigating insomnia disorder and insomnia symptoms and to meta‐analyse the estimates of heritability derived from these studies to generate an overall estimate of heritability. We further examined whether heritability was moderated by sex, age, reporter and insomnia symptom. A systematic literature search of five online databases was completed on 24 January 2020. Two authors independently screened 5644 abstracts, and 160 complete papers for the inclusion criteria of twin studies from the general population reporting heritability statistics on insomnia or insomnia symptoms, written in English, reporting data from independent studies. We ultimately included 12 papers in the meta‐analysis. The meta‐analysis focussed on twin intra‐class correlations for monozygotic and dizygotic twins. Based on these intra‐class correlations, the meta‐analytic estimate of heritability was estimated at 40%. Moderator analyses showed stronger heritability in females than males; and for parent‐reported insomnia symptoms compared with self‐reported insomnia symptoms. There were no other significant moderator effects, although this is likely because of the small number of studies that were comparable across levels of the moderators. Our meta‐analysis provides a robust estimate of the heritability of insomnia, which can inform future research aiming to uncover molecular genetic factors involved in insomnia vulnerability.
中文翻译：
失眠症的遗传性：双胞胎研究的荟萃分析
失眠症的双胞胎研究在遗传力估计中表现出异质性。这种异质性可能是由于性别差异、样本年龄、报告者和失眠症的定义。本研究的目的是系统地搜索有关失眠症和失眠症状的双胞胎研究文献，并对从这些研究中得出的遗传力估计值进行荟萃分析，以得出遗传力的总体估计值。我们进一步检查了遗传力是否受到性别、年龄、记者和失眠症状的影响。2020 年 1 月 24 日完成了对五个在线数据库的系统文献检索。两位作者独立筛选了 5644 篇摘要，以及 160 篇完整的论文，用于纳入普通人群的双胞胎研究纳入标准，报告失眠或失眠症状的遗传力统计数据，用英文撰写，报告来自独立研究的数据。我们最终在荟萃分析中纳入了 12 篇论文。该荟萃分析侧重于同卵双胞胎和异卵双胞胎的双胞胎组内相关性。基于这些类内相关性，遗传力的荟萃分析估计估计为 40%。调节分析显示女性的遗传力比男性强；并将父母报告的失眠症状与自我报告的失眠症状进行比较。没有其他显着的调节效应，尽管这可能是因为在调节水平之间具有可比性的研究数量较少。
更新日期：2020-11-21
中文翻译：
失眠症的遗传性：双胞胎研究的荟萃分析
失眠症的双胞胎研究在遗传力估计中表现出异质性。这种异质性可能是由于性别差异、样本年龄、报告者和失眠症的定义。本研究的目的是系统地搜索有关失眠症和失眠症状的双胞胎研究文献，并对从这些研究中得出的遗传力估计值进行荟萃分析，以得出遗传力的总体估计值。我们进一步检查了遗传力是否受到性别、年龄、记者和失眠症状的影响。2020 年 1 月 24 日完成了对五个在线数据库的系统文献检索。两位作者独立筛选了 5644 篇摘要，以及 160 篇完整的论文，用于纳入普通人群的双胞胎研究纳入标准，报告失眠或失眠症状的遗传力统计数据，用英文撰写，报告来自独立研究的数据。我们最终在荟萃分析中纳入了 12 篇论文。该荟萃分析侧重于同卵双胞胎和异卵双胞胎的双胞胎组内相关性。基于这些类内相关性，遗传力的荟萃分析估计估计为 40%。调节分析显示女性的遗传力比男性强；并将父母报告的失眠症状与自我报告的失眠症状进行比较。没有其他显着的调节效应，尽管这可能是因为在调节水平之间具有可比性的研究数量较少。
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