Abstract An efficient microwave assisted synthesis developed for a novel series of p-Tolyloxyquinoline-triazole hybrid derivatives and were synthesised starting from 2-(p-tolyloxy)quinoline-3-carbaldehyde and hydroxylacetophenes by using different chemical transformations. The target 1,2,3-triazole derivatives were obtained by 1,3-dipolar cycloaddition of azides with alkynes using CuI as a catalyst under microwave assisted method. The title compounds were screened for their antimicrobial activity, the result evident that most of the triazole derivatives were exhibited more potent antimicrobial activities.

中文翻译：

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新型对甲苯氧基喹啉-三唑杂化衍生物的高效微波辅助合成和抗菌活性。

摘要 一种高效的微波辅助合成方法是为一系列新型对甲苯氧基喹啉-三唑杂化衍生物而开发的，由 2-(对甲苯氧基)喹啉-3-甲醛和羟基苯乙酮通过不同的化学转化合成。以CuI为催化剂，在微波辅助下，通过叠氮化物与炔烃的1,3-偶极环加成反应获得目标1,2,3-三唑衍生物。筛选了标题化合物的抗微生物活性，结果表明大多数三唑衍生物表现出更有效的抗微生物活性。