Glioblastoma the most aggressive form of brain cancer, comprises a complex mixture of tumor cells and nonmalignant stromal cells, including neurons, astrocytes, microglia, infiltrating monocytes/macrophages, lymphocytes, and other cell types. All nonmalignant cells within and surrounding the tumor are affected by the presence of glioblastoma. Astrocytes use multiple modes of communication to interact with neighboring cells. Extracellular vesicle-directed intercellular communication has been found to be an important component of signaling between astrocytes and glioblastoma in tumor progression. In this review, we focus on recent findings on extracellular vesicle-mediated bilateral crosstalk, between glioblastoma cells and astrocytes, highlighting the protumor and antitumor roles of astrocytes in glioblastoma development.

中文翻译：

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细胞外囊泡介导的胶质母细胞瘤和星形胶质细胞之间的双边通讯

胶质母细胞瘤是最具侵袭性的脑癌形式，包括肿瘤细胞和非恶性基质细胞的复杂混合物，包括神经元、星形胶质细胞、小胶质细胞、浸润性单核细胞/巨噬细胞、淋巴细胞和其他细胞类型。肿瘤内和肿瘤周围的所有非恶性细胞都受到胶质母细胞瘤的影响。星形胶质细胞使用多种通信方式与相邻细胞相互作用。已发现细胞外囊泡定向的细胞间通讯是肿瘤进展中星形胶质细胞和胶质母细胞瘤之间信号传导的重要组成部分。在这篇综述中，我们关注最近关于胶质母细胞瘤细胞和星形胶质细胞之间细胞外囊泡介导的双边串扰的发现，突出了星形胶质细胞在胶质母细胞瘤发展中的促肿瘤和抗肿瘤作用。