Difluorocarbene is a very active and widely used intermediate in organic synthesis. In this work, a room temperature difluorocarbene-mediated triclassification reaction of iododifluoroacetophenone (2) and secondary amines with mild condition, short reaction time (only 10 min) and high selectivity had been studied, which produced one of the following three substances: N-CF₂H derivatives (up to 87% yield), formamides (82–89% yield) or the recycled starting secondary amines. This phenomenon was related to the structural stability of the corresponding products. If unstable, it would be hydrolyzed to formamides first, and then further hydrolyzed to starting amines. Based on the geometric structure of the raw materials, the corresponding prediction tree model was established, which provided guidance for the further application of difluoromethylation of Vemurafenib (1ee) and AZD9291 (1ff).

二氟卡宾是有机合成中非常活泼且广泛使用的中间体。在这项工作中，研究了室温二氟卡宾介导的碘二氟苯乙酮（2）和仲胺在温和条件下，短反应时间（仅10分钟）和高选择性下的三分类反应，产生了以下三种物质之一：N- CF ₂H衍生物（产率高达87％），甲酰胺（产率82-89％）或再循环的起始仲胺。这种现象与相应产品的结构稳定性有关。如果不稳定，则将其首先水解为甲酰胺，然后进一步水解为起始胺。根据原料的几何结构，建立了相应的预测树模型，为Vemurafenib（1ee）和AZD9291（1ff）的二氟甲基化的进一步应用提供了指导。