Tadalafil (TDL) is a phosphodiesterase-5 inhibitor (PDE5I), indicated for erectile dysfunction (ED). However, TDL exhibits poor aqueous solubility and dissolution rate, which may limit its application. This study aims to prepare amorphous solid dispersion (ASD) by spray-drying, using glycyrrhizin-a natural drug carrier. Particle and physicochemical characterizations were performed by particle size, polydispersity index measurement, yield, drug content estimation, Fourier Transformed Infrared (FTIR) spectroscopy, Differential scanning calorimetry (DSC), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM) and dissolution study. In order to evaluate the aphrodisiac activity of the prepared ASD, sexual behavior study was performed in male rats. It is further considered for the stability study. Our results revealed that TDL-GLZ spray-dried dispersion was a successful drug-carrier binary mixture. XRD and SEM showed that ASD of TDL with GLZ presented in the amorphous state and dented-spherical shape, unlike the drug indicating crystalline and spiked shaped. The optimized ASD3 formulation with particle size (1.92 µm), PDI (0.32), yield (97.78%) and drug content (85.00%) showed 4.07 folds’ increase in dissolution rate compared to pure TDL. The results obtained from the in vivo study exhibit significantly improved aphrodisiac activity with ASD3. The stability study revealed that the prepared ASD3 did not show any remarkable changes in the dissolution and drug content for 1 month storage at room temperature.

他达拉非 (TDL) 是一种磷酸二酯酶 5 抑制剂 (PDE5I)，适用于治疗勃起功能障碍 (ED)。然而，TDL的水溶性和溶出速率较差，这可能限制了其应用。本研究旨在利用天然药物载体甘草甜素，通过喷雾干燥制备无定形固体分散体（ASD）。通过粒径、多分散指数测量、产率、药物含量估算、傅里叶变换红外 (FTIR) 光谱、差示扫描量热法 (DSC)、X 射线衍射 (XRD)、扫描电子显微镜 (SEM) 和溶出度研究。为了评价所制备的ASD的壮阳活性，对雄性大鼠进行了性行为研究。进一步考虑稳定性研究。我们的结果表明，TDL-GLZ 喷雾干燥分散体是一种成功的药物载体二元混合物。 XRD和SEM表明，含有GLZ的TDL的ASD呈无定形状态和凹陷球形，与药物显示的结晶和尖峰形状不同。优化后的 ASD3 制剂的粒径（1.92 µm）、PDI（0.32）、产率（97.78%）和药物含量（85.00%）与纯 TDL 相比，溶出度提高了 4.07 倍。体内研究结果表明 ASD3 显着改善了催情活性。稳定性研究表明，所制备的ASD3在室温下保存1个月，溶出度和药物含量没有出现任何明显变化。