An increasing number of neuroimaging studies have implicated alterations of white matter in obsessive-compulsive disorder (OCD). The myelin oligodendrocyte glycoprotein (MOG) gene plays a major role in myelination, and has previously demonstrated significant association with this disorder, thus variations in this gene may contribute to observed white matter alterations. The purpose of this study is to examine the relationship between white matter volume in OCD and genetic variations in the MOG gene. Two polymorphisms in the MOG gene, MOG(C1334T) and MOG(C10991T), were investigated for association with total white matter volume as measured using volumetric magnetic resonance imaging in 37 pediatric OCD patients. We compared white matter volumes between allele and genotype groups for each polymorphism using ANCOVA. A significant relationship was detected between genotype C/C of MOG(C10991T) and decreased total white matter volume (P = 0.016). Our results showed an association between a MOG genetic variant and white matter volume. This finding is intriguing in light of the posited role of white matter alteration in the etiology of at least some cases of childhood-onset OCD. Further investigation with larger samples and sub-regional white matter volume phenotypes is warranted.

中文翻译：

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小儿强迫症中髓鞘少突胶质细胞糖蛋白 (MOG) 基因变异与白质体积的关联

越来越多的神经影像学研究涉及强迫症 (OCD) 中白质的改变。髓鞘少突胶质细胞糖蛋白 (MOG) 基因在髓鞘形成中起主要作用，并且先前已证明与这种疾病有显着关联，因此该基因的变异可能有助于观察到的白质改变。本研究的目的是检查强迫症中白质体积与 MOG 基因遗传变异之间的关系。MOG 基因中的两个多态性，MOG(C1334T) 和 MOG(C10991T)，在 37 名儿童强迫症患者中使用体积磁共振成像测量与总白质体积的关联进行了调查。我们使用 ANCOVA 比较了每个多态性的等位基因和基因型组之间的白质体积。MOG(C10991T)的基因型C/C与总白质体积减少之间存在显着相关性(P = 0.016)。我们的结果显示 MOG 遗传变异与白质体积之间存在关联。鉴于白质改变在至少某些儿童期强迫症病例的病因中的假定作用，这一发现很有趣。有必要对更大的样本和亚区域白质体积表型进行进一步调查。