The immunohistochemical pattern of kynurenine aminotransferase-2 (KAT-2) - the key role enzyme in the production of neuroactive and neuroprotective kynurenic acid (KYNA) - was studied in the cerebellum of mice. It is known from literature that KAT-2 is localized mainly in astrocytes in different parts of the cerebrum. Kynurenine aminotransferase (KAT) activity in the cerebellum is relatively low and alternative production routes for KYNA have been described there. Therefore we examined the immunohistochemical pattern of KAT-2 in this part of the brain. Surprisingly, the cellular localization of KAT-2 in mice was proven to be unique; it localized characteristically in Purkinje cells and in some other types of neurons (not identified) but was not found in astrocytes nor microglia. The exclusive neuronal, but not glial localization of KAT-2 in the cerebellum is novel and may be related to its low activity and to the alternative pathways for KYNA production that have been described.

在小鼠小脑中研究了犬尿氨酸转氨酶-2 (KAT-2) 的免疫组织化学模式 - 在产生神经活性和神经保护犬尿氨酸 (KYNA) 中的关键作用酶。从文献可知，KAT-2主要定位于大脑不同部位的星形胶质细胞中。小脑中犬尿氨酸氨基转移酶 (KAT) 的活性相对较低，并且已经描述了 KYNA 的替代生产路线。因此，我们检查了这部分大脑中 KAT-2 的免疫组织化学模式。令人惊讶的是，KAT-2 在小鼠中的细胞定位被证明是独一无二的。它在浦肯野细胞和一些其他类型的神经元（未鉴定）中特征性地定位，但在星形胶质细胞和小胶质细胞中均未发现。独有的神经元，