Natural polymer-based hybrid nanocomposites have been proposed as one of the most promising tools for biomedical applications, including disease treatment and diagnosis procedures. Xyloglucan nanocapsules can simultaneously load magnetic iron oxide nanoparticles and bioactive for a specific tissue, reducing the processes of degradation and metabolic inactivation of molecules with biological activity. In this work, magnetic nanocapsules of xyloglucan loaded with hydrophilic sulfated quercetin (MNXQ_SO₃) were successfully synthesized by inverse miniemulsion process through interfacial polymerization. The polymeric shell formation of nanocapsules was evidenced by Fourier Transform Infrared spectroscopy and Transmission Electron Microscopy. The ferrofluid (Fe₃O₄@PAAS) incorporated into the xyloglucan nanocapsules was synthesized by hydrothermal method, using polyacrylic acid sodium salt as coating. Dynamic Light Scattering technique confirmed the nanomeric dimensions (202.3 nm) and the good colloidal stability (−40.2 mV) of MNXQ_SO₃. The saturation magnetization analyzes pointed out the superparamagnetic behavior of Fe₃O₄@PAAS (48 emu/g) and MNXQ_SO₃ (4.2 emu/g). MNXQ_SO₃ was able to modify the release profile of sulfated quercetin (67%) when compared to the free bioactive (100%), exhibiting a release profile compatible with the zero-order kinetic model. The results showed that the development of MNXQ_SO₃ presents a new perspective for biomedical applications, including studies of targeted drug delivery.

天然高分子杂化纳米复合材料已被提出作为生物医学应用（包括疾病治疗和诊断程序）中最有前途的工具之一。木葡聚糖纳米胶囊可同时装载磁性氧化铁纳米颗粒并对特定组织具有生物活性，从而减少具有生物活性的分子的降解和代谢失活过程。在这项工作中，通过界面聚合通过逆细乳液法成功地合成了载有亲水性硫酸槲皮素（MNXQ_SO ₃）的木葡聚糖磁性纳米胶囊。纳米胶囊的聚合物壳形成通过傅里叶变换红外光谱和透射电子显微镜证明。铁磁流体（Fe ₃ O ₄采用聚丙烯酸钠盐为涂层，通过水热法合成了并入木葡聚糖纳米胶囊中的@PAAS。动态光散射技术证实了nanomeric尺寸（202.3纳米）和MNXQ_SO的良好的胶体稳定性（-40.2毫伏）₃。饱和磁化强度分析表明，Fe ₃ O ₄ @PAAS（48 emu / g）和MNXQ_SO ₃（4.2 emu / g）的超顺磁行为。与游离生物活性物质（100％）相比，MNXQ_SO ₃能够改变硫酸槲皮素的释放曲线（67％），表现出与零级动力学模型兼容的释放曲线。结果表明，MNXQ_SO ₃的开发 提出了生物医学应用的新观点，包括靶向药物递送的研究。