As a structural analog of graphene and boron nitride, hexagonal boron carbonitride nanosheets (BCNNSs) are supposed to be a potential drug deliverer. In the present work, an improved solid-state reaction method combined with ultrasonic exfoliating was reported for preparing BCNNSs. Vapor-solid (VS) mechanism was proposed to be responsible for the formation of BCNNSs. The BCNNSs were further modified by DSPE-mPEG-5000 to improve their dispersion in aqueous solution. It was found that the BCNNSs-PEG nanocomplex could be efficiently taken in by MDA-MB-231 breast cancer cells evidenced by inverted fluorescence microscopy. The PEGylated BCNNSs showed an outstanding ability to load paclitaxel through π-π interaction and hydrophobic interaction, and BCNNSs-PEG-loaded paclitaxel presented higher cytotoxicity in comparison with free paclitaxel. BCNNSs may become a promising candidate for delivering paclitaxel and other hydrophobic drugs.

作为石墨烯和氮化硼的结构类似物，六角形碳氮化硼纳米片（BCNNS）被认为是潜在的药物释放剂。在目前的工作中，报道了一种改进的固态反应方法与超声剥落相结合来制备BCNNSs。提出了汽固（VS）机制负责BCNNSs的形成。通过DSPE-mPEG-5000对BCNNS进行了进一步修饰，以改善其在水溶液中的分散性。发现通过倒置荧光显微镜法证明，MDA-MB-231乳腺癌细胞可以有效地吸收BCNNSs-PEG纳米复合物。聚乙二醇化的BCNNSs具有通过π-π相互作用和疏水相互作用负载紫杉醇的出色能力，与游离的紫杉醇相比，BCNNSs-PEG负载的紫杉醇具有更高的细胞毒性。