Introduction

Excess energy intake by spectators at a sporting event (i.e., a tailgate) might cause acute negative health effects. However, limited data exist regarding the effects of overeating and alcohol consumption on lipid metabolism and the potential to gain intrahepatic triacylglycerols (IHTG). We tested the hypothesis that overconsumption of food and alcohol would significantly increase both hepatic de novo lipogenesis (DNL) and IHTG.

Methods

Eighteen males (mean±SD, age: 31.4±7.3 y, BMI: 32.1±5.9 kg/m²) were fed alcoholic drinks to elevate blood alcohol for 5hr, while highly-palatable food was presented. Blood samples were collected and DNL in TG-rich lipoproteins (TRL) was measured by GC/MS, IHTG was measured via MRS (n=15), and substrate oxidation via indirect calorimetry.

Results

Subjects consumed 5,087±149 kcal (191±25% excess of total daily energy needs including 171±24g alcohol), which increased plasma insulin, glucose, TG, and decreased NEFA (ANOVA P≤0.003 for all). Both DNL and TRL-TG increased (P<0.001) while IHTG did not change in the group as a whole (P=0.229). Individual subject data revealed remarkably differing responses for IHTG (9 increased, 5 decreased, 1 did not change). Despite maintaining equal breath alcohol levels, subjects with IHTG elevations exhibited higher DNL, consumed 90% less alcohol (P=0.048), tended to consume more carbohydrates, and exhibited lower whole-body fat oxidation (not significant) compared to those whose IHTG was reduced.

Discussion

This study demonstrate that acute excess energy intake may have differing effects on an individual’s DNL and IHTG, and dietary carbohydrate may impact DNL more than alcohol.

ClinicalTrials.gov Identifier

NCT02141880.

中文翻译：

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尾门研究：过度饮食对代谢的不同影响

介绍

观众在体育赛事（即尾门）中摄入过多的能量可能会导致严重的负面健康影响。然而，关于暴饮暴食和饮酒对脂质代谢的影响以及获得肝内三酰甘油 (IHTG) 的可能性的数据有限。我们检验了过度消费食物和酒精会显着增加肝脏新生脂肪生成 (DNL) 和 IHTG 的假设。

方法

18 名男性（平均值±标准差，年龄：31.4±7.3 岁，BMI：32.1±5.9 kg/m ²）被喂食酒精饮料以提高血液酒精含量 5 小时，同时提供可口的食物。采集血样并通过 GC/MS 测量富含 TG 的脂蛋白 (TRL) 中的 DNL，通过 MRS (n=15) 测量 IHTG，通过间接量热法测量底物氧化。

结果

受试者消耗了 5,087±149 kcal（超过每日总能量需求的 191±25%，包括 171±24g 酒精），这会增加血浆胰岛素、葡萄糖、TG 和降低 NEFA（所有方差分析P ≤0.003）。DNL 和 TRL-TG 均增加（P < 0.001），而 IHTG 在整个组中没有变化（P = 0.229）。个体受试者数据显示对 IHTG 的反应显着不同（9 个增加，5 个减少，1 个没有变化）。尽管保持相同的呼气酒精水平，与 IHTG 升高的受试者相比，IHTG 升高的受试者表现出更高的 DNL，消耗的酒精减少 90%（P = 0.048），倾向于消耗更多的碳水化合物，并且表现出较低的全身脂肪氧化（不显着）减少。

讨论

这项研究表明，急性过量的能量摄入可能对个人的 DNL 和 IHTG 产生不同的影响，而膳食碳水化合物对 DNL 的影响可能比酒精更大。

ClinicalTrials.gov 标识符

NCT02141880。