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Dual-Wavelength Photosensitive Nano-in-Micro Scaffold Regulates Innate and Adaptive Immune Responses for Osteogenesis
Nano-Micro Letters ( IF 31.6 ) Pub Date : 2020-11-21 , DOI: 10.1007/s40820-020-00540-z
Qin Zhao 1 , Miusi Shi 1 , Chengcheng Yin 1 , Zifan Zhao 1 , Jinglun Zhang 1 , Jinyang Wang 1 , Kailun Shen 1 , Lingling Zhang 1, 2 , Hua Tang 3 , Yin Xiao 4 , Yufeng Zhang 1, 2
Affiliation  

  • The controlled release of IL-4 and dexamethasone by a dual-wavelength photosensitive nano-in-micro scaffold (biphasic calcium phosphate loaded with goad nanocage, BCP-GNC) enables the regulation of specific immune cells and immune responses.

  • BCP-GNC regulates innate and adaptive immune responses in two stages (directing the M2 polarization of macrophages and inhibiting the maturation of dendritic cells) to promote osteoinduction.



中文翻译:

双波长光敏纳米-微型支架调节成骨的先天和适应性免疫反应

  • 通过双波长光敏纳米微支架(装载有刺针纳米笼的双相磷酸钙,BCP-GNC)控制释放 IL-4 和地塞米松,可以调节特定的免疫细胞和免疫反应。

  • BCP-GNC 在两个阶段(指导巨噬细胞的 M2 极化和抑制树突状细胞的成熟)调节先天性和适应性免疫反应,以促进骨诱导。

更新日期:2020-11-22
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