A nontoxic multicarboxylic acid (critic acid) was incorporated into the chitosan/poly(ethylene oxide) composite nanofibers by electrospinning. Critic acid was used to crosslink the chitosan molecules inside the composite nanofibers at elevated temperature, which were characterized by FT-IR and XPS analyses. By increasing the critic acid loading and annealing temperature, the solvent resistance and mechanical properties of these composite nanofibers could be significantly improved. Aspirin, a model drug, has been incorporated into the composite nanofibers and the corresponding drug release performances in PBS solution were evaluated. With the increasing of annealing temperature, the drug release rate of the composite nanofibers was decreasing, which could be ascribed to the reduced swelling ratio and concentration of free volume holes in composite nanofibers. Moreover, the cumulative released aspirin amount in certain release time could be finely tuned by adjusting the initial aspirin loading in the composite nanofibers.

通过电纺丝将无毒的多元羧酸（苯甲酸）掺入壳聚糖/聚（环氧乙烷）复合纳米纤维中。在高温下，使用丙酮酸使壳聚糖分子在复合纳米纤维内部交联，这通过FT-IR和XPS分析进行了表征。通过提高批评者的酸负荷和退火温度，可以显着提高这些复合纳米纤维的耐溶剂性和机械性能。阿司匹林（一种模型药物）已被掺入复合纳米纤维中，并评估了其在PBS溶液中的相应药物释放性能。随着退火温度的升高，复合纳米纤维的释药速率逐渐降低，这可以归因于复合纳米纤维中的溶胀率和自由体积孔浓度降低。此外，可以通过调节复合纳米纤维中的初始阿司匹林负荷来微调在特定释放时间内累积的阿司匹林释放量。