Here, we design and synthesize a novel 2D Cu-tetrakis(4-carboxyphenyl)porphyrin (TCPP) metal–organic framework (MOF) sheet and ultrasmall Cu_5.4O nanoparticle (Cu_5.4O USNP) hybrid (Cu-TCPP MOF/Cu_5.4O nanocomposite). The graphene-like ultrathin Cu-TCPP MOF sheets offer high surface-to-volume atom ratios and many active sites, which is beneficial for loading more Cu_5.4O USNPs. The Cu_5.4O USNPs with ultrasmall size (<5 nm) have promising conductivity and excellent enzymatic ability for H₂O₂. The successfully prepared nanocomposites are characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and Fourier transform infrared (FT-IR) techniques. The 2D graphene-like ultrathin Cu-TCPP MOF sheets show no H₂O₂-sensing signals, whereas Cu_5.4O USNPs exhibit a clear reduction peak for detection of H₂O₂. Interestingly, the combination of two kinds of nanomaterials improved the H₂O₂ sensing ability due to their synergistic effect. The properties of the unmodified electrodes and the Cu-TCPP MOF/Cu_5.4O nanocomposite-modified electrodes were systemically studied by cyclic voltammetry (CV), current-time (i-t) response, and square-wave voltammetry (SWV) techniques. The electrochemical sensor for the detection of H₂O₂ based on the Cu-TCPP MOF/Cu_5.4O nanocomposite has a lower detection limit of 0.13 μmol·L⁻¹ and wider linear range of 0.1 × 10⁻⁶ ~ 0.59 × 10⁻³ mol·L⁻¹ and 1.59 × 10⁻³ ~ 20.59 × 10⁻³ mol·L⁻¹ when compared with the Cu_5.4O USNPs-modified electrode. The electrochemical sensor can be further used to detect H₂O₂ produced by cells.

在这里，我们设计并合成了一种新型的二维Cu-四（4-羧基苯基）卟啉（TCPP）金属-有机骨架（MOF）薄板和超小型Cu _5.4 O纳米颗粒（Cu _5.4 O USNP）杂化体（Cu-TCPP MOF / Cu _5.4 O纳米复合材料）。类似于石墨烯的超薄Cu-TCPP MOF片材具有高的表面体积比和许多活性位，这有利于负载更多的Cu _5.4 O USNP。具有超小尺寸（<5 nm）的Cu _5.4 O USNP具有良好的电导率和出色的H ₂ O ₂酶促能力。成功制备的纳米复合材料的特征在于透射电子显微镜（TEM），扫描电子显微镜（SEM），X射线光电子能谱（XPS），X射线衍射（XRD）和傅里叶变换红外（FT-IR）技术。二维石墨烯状超薄Cu-TCPP MOF片未显示H ₂ O ₂感测信号，而Cu _5.4 O USNP显示出明显的还原峰，可用于检测H ₂ O ₂。有趣的是，两种纳米材料的组合由于它们的协同作用而提高了H ₂ O _2的感测能力。未经修饰的电极和Cu-TCPP MOF / Cu _5.4的特性通过循环伏安法（CV），电流时间（i - t）响应和方波伏安法（SWV）技术对O纳米复合修饰电极进行了系统研究。用于检测H的电化学传感器₂ ö ₂基于在Cu-TCPP MOF /铜_5.4 ø纳米复合材料具有0.13μmol·L的检测下限^-1和更宽的线性范围为0.1×10 ^-6  〜0.59×10 ^{- 3} 莫尔^-1和1.59×10 ^-3  〜20.59×10 ^-3 摩尔· ^-1当与铜相比_5.4O USNPs修饰的电极。电化学传感器可以进一步用于检测细胞产生的H ₂ O ₂。