Ion mobility spectrometers can detect gaseous compounds at atmospheric pressure in the range of parts per trillion within a second. Due to their fast response times, high sensitivity, and limited instrumental effort, they are used in a variety of applications, especially as mobile or hand-held devices. However, most real-life samples are gas mixtures, which can pose a challenge for IMS with atmospheric pressure chemical ionization mainly due to competing gas-phase ionization processes. Therefore, we present a miniaturized drift tube IMS coupled to a compact gas chromatograph for pre-separation, built of seven bundled standard GC columns (Rtx-Volatiles, Restek GmbH) with 250 μm ID and 1.07 m in length. Such pre-separation significantly reduces chemical cross sensitivities caused by competing gas-phase ionization processes and adds orthogonality. Our miniaturized GC-IMS system is characterized with alcohols, halocarbons, and ketones as model substances, reaching detection limits down to 70 ppt_v with IMS averaging times of just 125 ms. It separates test mixtures of ketones and halocarbons within 180 s and 50 s, respectively. The IMS has a short drift length of 40.6 mm and reaches a high resolving power of R_P = 68.

离子淌度光谱仪可以在大气压下在一秒内检测万亿分之一范围内的气态化合物。由于其响应时间快、灵敏度高且仪器工作量有限，因此它们被用于各种应用，特别是作为移动或手持设备。然而，大多数现实生活中的样品都是气体混合物，这对采用大气压化学电离的 IMS 提出了挑战，这主要是由于气相电离过程的竞争。因此，我们提出了一种小型化漂移管 IMS，与紧凑型气相色谱仪结合用于预分离，由七个捆绑的标准 GC 柱（Rtx-Volatiles，Restek GmbH）组成，内径为 250 μm，长度为 1.07 m。这种预分离显着降低了由竞争性气相电离过程引起的化学交叉敏感性并增加了正交性。我们的小型 GC-IMS 系统以醇类、卤代烃和酮类为模型物质，检测限低至 70 ppt _v ，IMS 平均时间仅为 125 毫秒。它分别在 180 秒和 50 秒内分离酮和卤化碳的测试混合物。 IMS 的漂移长度较短，为 40.6 mm，分辨率较高_， RP = 68。