Ion mobility spectrometers can detect gaseous compounds at atmospheric pressure in the range of parts per trillion within a second. Due to their fast response times, high sensitivity, and limited instrumental effort, they are used in a variety of applications, especially as mobile or hand-held devices. However, most real-life samples are gas mixtures, which can pose a challenge for IMS with atmospheric pressure chemical ionization mainly due to competing gas-phase ionization processes. Therefore, we present a miniaturized drift tube IMS coupled to a compact gas chromatograph for pre-separation, built of seven bundled standard GC columns (Rtx-Volatiles, Restek GmbH) with 250 μm ID and 1.07 m in length. Such pre-separation significantly reduces chemical cross sensitivities caused by competing gas-phase ionization processes and adds orthogonality. Our miniaturized GC-IMS system is characterized with alcohols, halocarbons, and ketones as model substances, reaching detection limits down to 70 ppt_v with IMS averaging times of just 125 ms. It separates test mixtures of ketones and halocarbons within 180 s and 50 s, respectively. The IMS has a short drift length of 40.6 mm and reaches a high resolving power of R_P = 68.

离子迁移谱仪可以在大气压下在一秒钟内检测到气态化合物，其范围为万亿分之一。由于它们的快速响应时间，高灵敏度和有限的仪器工作量，它们被用于各种应用中，尤其是作为移动或手持式设备。但是，大多数现实生活中的样品都是气体混合物，这主要是由于竞争性的气相电离过程，对具有大气压化学电离的IMS构成了挑战。因此，我们提出了一种与紧凑型气相色谱仪相连的微型化漂移管IMS，以进行预分离，该质谱仪由7个捆绑的标准GC色谱柱（Rtx-Volatiles，Restek GmbH）构建，内径250μm，长度1.07 m。这种预分离大大降低了由竞争的气相电离过程引起的化学交叉敏感性，并增加了正交性。_v IMS平均时间仅为125毫秒。它可以分别在180 s和50 s内分离出酮和卤代烃的测试混合物。IMS的漂移长度很短，为40.6 mm，并且具有较高的分辨力R _P  = 68。