Park et al. question one out of seven findings from Hadzipasic et al.: whether TPX2 allosterically regulates the oldest Aurora. We had already addressed the two concerns raised—sparse sequence sampling and not forcing the gene to the species tree—before publication. Moreover, we believe their ancestral sequence reconstruction would be consistent with a nonallosteric common ancestor, and we show large sequence differences caused by species tree–enforced gene trees.

中文翻译：

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对“丝氨酸-苏氨酸激酶变构激活的古老起源”评论的回应

帕克等人。对 Hadzipasic 等人的七分之一发现提出疑问：TPX2 是否对最古老的极光进行变构调节。在发表之前，我们已经解决了提出的两个问题——稀疏序列采样和不强制基因进入物种树。此外，我们相信他们的祖先序列重建将与非变构共同祖先一致，并且我们显示出由物种树强制基因树引起的巨大序列差异。