The Strychnos alkaloid minfiensine and its analogs among the akuammiline alkaloids have a variety of biological activities, including anti-tumor and analgesic activities, and have therefore attracted considerable synthetic interest. Here we provide an overview of recent advances in methodologies for the construction of the characteristic tetracyclic hydrocarbazole core structure containing a fused pyrrolidine ring at C4a and C9a.

中文翻译：

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Minfiensine及其相关的Akuammiline生物碱的C4a，C9a融合四环咔唑核心结构合成策略的最新进展

的马钱子生物碱minfiensine及其akuammiline生物碱类似物中具有多种生物活性，包括抗肿瘤和镇痛活性，因此引起了极大的兴趣合成。在这里，我们提供了在具有特征的四环咔唑核心结构的构建方法方面的最新进展概述，该结构在C4a和C9a处含有稠合的吡咯烷环。