Reactive crystallization: a review,Reaction Chemistry & Engineering

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Reactive crystallization: a review
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2020-11-16 , DOI: 10.1039/d0re00272k
Matthew A. McDonald _{1,

2,

3,

4} , Hossein Salami _{1,

2,

3,

4} , Patrick R. Harris _{1,

2,

3,

4} , Colton E. Lagerman _{1,

2,

3,

4} , Xiaochuan Yang _{4,

5,

6,

7,

8} , Andreas S. Bommarius _{1,

2,

3,

4} , Martha A. Grover _{1,

2,

3,

4} , Ronald W. Rousseau _{1,

2,

3,

4}

Affiliation

Reactive crystallization is not new, but there has been recent growth in its use as a means of improving performance and sustainability of industrial processes. This review examines phenomena and processes in which reaction and crystallization are coupled in the production of a desired chemical species. Coverage includes fundamental phenomena, such as solubility, supersaturation, crystal nucleation and growth, and chemical kinetics. Systems examined are divided into two groups, those best described as undergoing ionic reactions (including neutralizations), which have near instantaneous rates and result in the formation of ionic bonds, and those undergoing covalent reactions in which the key step occurs at measurable rates and results in the formation of covalent bonds. Discussion of the latter category also includes the impact of catalysis. Examples of a variety of reactions and applications are enumerated, and special attention is given to the utility of reactive crystallization in chiral resolution. Integration of reactive crystallization into process design, including both batch and continuous operations, and the development and efficacy of modeling, monitoring and control are reviewed. Finally, a perspective addressing needs to advance the usefulness and applications of reactive crystallization is included.

中文翻译：

反应结晶：综述

反应结晶并不是什么新鲜事物，但是最近作为一种改善工业过程的性能和可持续性的手段，其用途已有所增长。这篇综述研究了在所需化学物质的生产中反应和结晶耦合的现象和过程。涵盖范围包括基本现象，例如溶解度，过饱和，晶体成核和生长以及化学动力学。所检查的系统分为两组，最能描述为正在进行离子反应（包括中和）的系统，它们具有接近瞬时的速率并导致离子键的形成，而正在进行共价反应的系统中的关键步骤以可测量的速率和结果发生。共价键的形成。关于后一类的讨论还包括催化的影响。列举了各种反应和应用的实例，并特别注意了反应性结晶在手性拆分中的效用。回顾了反应结晶在工艺设计中的集成，包括分批和连续操作，以及建模，监控和控制的开发和功效。最后，包括解决提高反应性结晶的用途和应用的需求的观点。

更新日期：2020-11-21

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