Diabetes mellitus is a major public health issue related to the irregular metabolism of carbohydrates, protein, and fat. It occurs due to insufficient insulin production and insulin action. Cucumis melo possesses several biological properties including antioxidant, anti-inflammatory, antibacterial, antihypothyroidism, and antiangiogenic activities. The objective of the present study was to determine the antidiabetic and antihyperlipidemic activities of Cucumis melo var. momordica fruit extract on experimental animals. Results show that treatment with C. melo fruit extract and fraction caused a reduction in blood glucose levels. Cucumis melo toluene fraction (CMTF) exhibited a significant (*P < 0.05) reduction of blood glucose level on the 28th day, i.e., 122 mg/dL, in comparison with the positive control group (streptozotocin (STZ)). However, the extract of C. melo showed less significant results in comparison with CMTF. Triglyceride, LDL, and VLDL levels were increased chronically due to STZ and were significantly (*P < 0.05) restored to 84.16, 86.97, and 19.73, respectively, by CMTF in comparison with the positive control group (STZ in the dose of 55 mg/kg). The extract-treated groups also showed similar results as CMTF, but their efficacy was lesser than CMTF. It is can be concluded that C. melo fruits can be used as an effective antidiabetic and antihyperlipidemic drug.

中文翻译：

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黄瓜的抗糖尿病和降血脂活性。苦瓜提取物对实验动物的影响

糖尿病是与碳水化合物，蛋白质和脂肪的不规则代谢有关的主要公共卫生问题。它是由于胰岛素生成和胰岛素作用不足而发生的。黄瓜具有多种生物学特性，包括抗氧化剂，抗炎，抗菌，抗甲状腺功能低下和抗血管生成活性。本研究的目的是确定黄瓜的抗糖尿病和降血脂活性。苦瓜果实提取物对实验动物的影响。结果表明，用C. melo水果提取物和级分处理可降低血糖水平。与阳性对照组（链脲佐菌素（STZ））相比，黄瓜甜瓜甲苯级分（CMTF）在第28天的血糖水平显着降低（* P <0.05），即122 mg / dL。然而，与CMTF相比，C。melo提取物显示的结果不那么重要。甘油三酯，LDL和VLDL水平由于STZ而长期升高，与阳性对照组（STZ剂量为55 mg）相比，CMTF分别将甘油三酯，LDL和VLDL水平分别显着（* P <0.05）恢复至84.16、86.97和19.73 /公斤）。提取物治疗组也显示出与CMTF相似的结果，但其疗效低于CMTF。可以得出结论，甜瓜果可以用作有效的抗糖尿病和降血脂药。CMTF与阳性对照组比较（STZ剂量为55 mg / kg）。提取物治疗组也显示出与CMTF相似的结果，但其疗效低于CMTF。可以得出结论，甜瓜果可以用作有效的抗糖尿病和降血脂药。CMTF与阳性对照组比较（STZ剂量为55 mg / kg）。提取物治疗组也显示出与CMTF相似的结果，但其疗效低于CMTF。可以得出结论，甜瓜果可以用作有效的抗糖尿病和降血脂药。