Highly biocompatible and recyclable biomimetic nanoparticles for antibiotic-resistant bacteria infection,Biomaterials Science

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Highly biocompatible and recyclable biomimetic nanoparticles for antibiotic-resistant bacteria infection
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-11-9 , DOI: 10.1039/d0bm01397h
Bei Chen _{1,

2,

3,

4,

5} , Fangfang Li _{3,

6,

7,

8,

9} , Xin Kai Zhu _{1,

2,

3,

4,

5} , Wei Xie _{1,

2,

3,

4,

5} , Xue Hu _{4,

5,

10,

11} , Ming Hui Zan _{1,

2,

3,

4,

5} , XueKe Li _{3,

6,

7,

8,

9} , Qian-Ying Li _{3,

5,

9,

12} , Shi-Shang Guo _{1,

2,

3,

4,

5} , Xing-Zhong Zhao _{1,

2,

3,

4,

5} , Ying-an Jiang _{4,

5,

10,

11} , Zhijian Cao _{3,

6,

7,

8,

9} , Wei Liu _{1,

2,

3,

4,

5}

Affiliation

Increasing number of resistant bacteria have emerged with the overuse of antibiotics, which indicates that the bacterial infection has become a global challenge. Furthermore, the pollution of antibiotics to the environment has become a serious threat to public health. It is known that toxins produced by bacteria are the main cause of bacterial infections. Photothermal therapy is an effective antibacterial approach. However, the photothermal reagents cannot eliminate bacterial toxins, and even some anti-bacterial materials are toxic. Here, we synthesized a biomimetic recycled nanoparticle, red blood cell (RBC) membrane-coated Fe₃O₄ nanoparticles (RBC@Fe₃O₄), as an antibacterial agent. The RBC@Fe₃O₄ nanoparticles act as nano-sponges to trap toxins and then kill them all with a photothermal effect. We can describe this process simply as a battle between two armies. Our strategy is to disarm the “enemy” so that we can easily kill the “enemy” who has no power, which results in enhancing the bactericidal efficacy. The toxin of methicillin-resistant Staphylococcus aureus (MRSA) was absorbed by RBC@Fe₃O₄in vitro. In addition, in vivo studies proved that the RBC@Fe₃O₄ nanoparticles confer obvious survival benefits against toxin-induced lethality by absorbing the toxin of MRSA. Furthermore, using a mouse model of MRSA wound infection, the RBC@Fe₃O₄ nanoparticles with laser irradiation were found to have a superior wound-healing effect. Simultaneously, the RBC@Fe₃O₄ nanoparticles could be recycled in a simple way without affecting the bactericidal efficacy. The highly biocompatible and recyclable RBC@Fe₃O₄ biomimetic nanoparticles based on photothermal therapy and bacterial toxin adsorption strategy are promising for treating bacterial infections.

中文翻译：

具有高度生物相容性和可回收利用的仿生纳米颗粒，可用于抵抗抗生素的细菌感染

随着抗生素的过度使用，出现了越来越多的耐药细菌，这表明细菌感染已成为全球性挑战。此外，抗生素对环境的污染已经成为对公共健康的严重威胁。已知细菌产生的毒素是细菌感染的主要原因。光热疗法是一种有效的抗菌方法。但是，光热试剂无法消除细菌毒素，甚至某些抗菌材料也具有毒性。在这里，我们合成了一种仿生再生纳米颗粒，红细胞（RBC）膜包裹的Fe ₃ O ₄纳米颗粒（RBC @ Fe ₃ O ₄），作为抗菌剂。红细胞@Fe ₃ O_4种纳米颗粒充当纳米海绵来捕获毒素，然后通过光热作用杀死它们。我们可以简单地将这一过程描述为两军之间的战斗。我们的策略是解除“敌人”的武装，以便我们可以轻松地杀死无能为力的“敌人”，从而提高杀菌效力。耐甲氧西林金黄色葡萄球菌（MRSA）的毒素在体外被RBC @ Fe₃ O₄吸收。此外，体内研究证明，RBC @ Fe₃ O₄纳米颗粒通过吸收MRSA毒素，具有明显的生存优势，可抵抗毒素诱发的致死性。此外，使用MRSA伤口感染的小鼠模型，RBC @ Fe发现用激光辐照的₃ O₄纳米颗粒具有优异的伤口愈合效果。同时，RBC @ Fe₃ O₄纳米颗粒可以以简单的方式循环使用而不会影响杀菌效果。基于光热疗法和细菌毒素吸附策略的高度生物相容性和可回收的RBC @ Fe₃ O₄仿生纳米颗粒有望用于治疗细菌感染。

更新日期：2020-12-16

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