Construction of 2-(2-Arylphenyl)azoles via Cobalt-Catalyzed C–H/C–H Cross-Coupling Reactions and Evaluation of Their Antifungal Activity,Organic Letters

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Construction of 2-(2-Arylphenyl)azoles via Cobalt-Catalyzed C–H/C–H Cross-Coupling Reactions and Evaluation of Their Antifungal Activity
Organic Letters ( IF 4.9 ) Pub Date : 2020-11-20 , DOI: 10.1021/acs.orglett.0c03551
Xinmou Wang ₁ , Yuming Chen ₁ , Hongjian Song ₁ , Yuxiu Liu ₁ , Qingmin Wang _{1,

2}

Affiliation

Although compounds with a 2-(2-arylphenyl) benzoxazole motif are biologically important, there are only a few methods for synthesizing them. Herein, we report an efficient method for synthesis of such compounds by means of cobalt-catalyzed C–H/C–H cross-coupling reactions. This method has a broad substrate scope and good tolerance for sensitive functional groups. In addition, we demonstrate that introducing a heteroarene moiety to biphenyl compounds enhanced their antifungal activity.

中文翻译：

通过钴催化的 C-H/C-H 交叉偶联反应构建 2-（2-芳基苯基）唑并评估其抗真菌活性

尽管具有 2-(2-芳基苯基) 苯并恶唑基序的化合物在生物学上很重要，但合成它们的方法很少。在此，我们报告了一种通过钴催化的 C-H/C-H 交叉偶联反应合成此类化合物的有效方法。该方法具有广泛的底物范围和对敏感官能团的良好耐受性。此外，我们证明将杂芳烃部分引入联苯化合物增强了它们的抗真菌活性。

更新日期：2020-12-04

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