Drug delivery systems (DDSs) have great potential for improving the treatment of several diseases, especially microbial infections and cancers. However, the formulation procedures of DDSs remain challenging, especially at the nanoscale. Reducing batch-to-batch variation and enhancing production rate are some of the essential requirements for accelerating the translation of DDSs from a small scale to an industrial level. Microfluidic technologies have emerged as an alternative to the conventional bench methods to address these issues. By providing precise control over the fluid flows and rapid mixing, microfluidic systems can be used to fabricate and engineer different types of DDSs with specific properties for efficient delivery of a wide range of drugs and genetic materials. This review discusses the principles of controlled rapid mixing that have been employed in different microfluidic strategies for producing DDSs. Moreover, the impact of the microfluidic device design and parameters on the type and properties of DDS formulations was assessed, and recent applications in drug and gene delivery were also considered.

中文翻译：

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用于制备药物和基因传递系统的微流体技术的最新进展

药物递送系统 (DDS) 在改善多种疾病的治疗方面具有巨大潜力，尤其是微生物感染和癌症。然而，DDS 的配方程序仍然具有挑战性，尤其是在纳米级。减少批次间差异和提高生产率是加速 DDS 从小规模向工业水平转化的一些基本要求。微流体技术已成为解决这些问题的传统工作台方法的替代方案。通过提供对流体流动和快速混合的精确控制，微流体系统可用于制造和设计具有特定特性的不同类型的 DDS，以有效输送各种药物和遗传材料。这篇综述讨论了用于生产 DDS 的不同微流体策略中所采用的受控快速混合的原理。此外，还评估了微流体装置设计和参数对 DDS 制剂类型和特性的影响，并考虑了最近在药物和基因传递中的应用。