Eleven metabolites, six echinosporins (1–6), four dibenzoyls (7–10), and an aromatic compound (11), were isolated from the fermentation broth of lichen-associated Amycolatopsis hippodromi. The structures of the new compounds (1–5, 8–11) were elucidated by comprehensive spectroscopic analysis including data from experimental and calculated ECD spectra. Amycolasporins A–C (1–3) demonstrated antibacterial activities against Bacillus subtilis, Staphylococcus aureus, and Escherichia coli with MIC values of 25 or 100 μg/mL. Amycolasporin C (3) and the known dibenzoyl (7) attenuated the production of NO due to the suppression of the expression of nitric oxide synthase (iNOS) in LPS-induced RAW 264.7 cells in a dose-dependent manner.

中文翻译：

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来自地衣相关 Amycolatopsis hippodromi 的支链孢菌素和二苯甲酰及其抗菌和抗炎活性

十一代谢物，六个echinosporins（1 - 6），四个dibenzoyls（7 - 10），和芳族化合物（11），从地衣相关的发酵肉汤中分离拟无枝酸hippodromi。（新化合物的结构1 - 5，8 - 11）通过综合光谱分析包括从实验数据和计算ECD光谱阐明。Amycolasporins A–C ( 1–3 ) 显示出对枯草芽孢杆菌、金黄色葡萄球菌和大肠杆菌的抗菌活性MIC 值为 25 或 100 μg/mL。由于抑制 LPS 诱导的 RAW 264.7 细胞中一氧化氮合酶 (iNOS) 的表达，支链孢菌素 C ( 3 ) 和已知的二苯甲酰基 ( 7 ) 以剂量依赖性方式减弱了 NO 的产生。