The endocrine-disrupting chemical 4-tert-octylphenol (OP) is a widespread estrogenic chemical used in consumer products such as epoxy resins and polycarbonate plastic. However, the effects of OP on brain development are unknown. The present study examined the effects of OP on neuron and neurobehavioral development in mice. By using primary cortical neuron cultures, we found that OP-treated showed a decreased length of axons and dendrites and an increased number of primary and secondary dendrites. OP reduced bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation in offspring mouse brain. Moreover, OP induced apoptosis in neuronal progenitor cells in offspring mouse brain. Furthermore, offspring mice from OP-treated dams showed abnormal cognitive, social, and anxiety-like behaviors. Taken together, these results suggest that perinatal exposure to OP disrupts brain development and behavior in mice.

中文翻译：

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4-叔辛基酚暴露会破坏大脑发育，进而破坏运动，认知，社交和行为功能

破坏内分泌的化学物质4-叔辛基苯酚（OP）是一种广泛的雌激素化学物质，用于消费产品，例如环氧树脂和聚碳酸酯塑料。但是，OP对大脑发育的影响尚不清楚。本研究检查了OP对小鼠神经元和神经行为发育的影响。通过使用原代皮层神经元文化，我们发现OP治疗显示轴突和树突的长度减少和原发和继发树突的数量增加。OP减少了溴脱氧尿苷（BrdU），有丝分裂标记物Ki67和磷酸化组蛋白H3（p-组蛋白-H3），导致后代小鼠大脑神经元祖细胞增殖减少。此外，OP诱导后代小鼠大脑神经元祖细胞的凋亡。此外，OP处理水坝的后代小鼠表现出异常的认知，社交，和类似焦虑的行为。两者合计，这些结果表明围产期暴露于OP会破坏小鼠的大脑发育和行为。