Stomach ulcer is an endemic gastrointestinal disorder which constitutes a major public health problem all over the world. Stomach ulcer results when there is an imbalance between the protective factors (mucus and bicarbonate) and aggressive factors (acid and pepsin) in the stomach. Dried powdered leaves and stem of the phytomedicine Euphorbia hirta (E. hirta) (1000 g) was extracted with methanol using a soxhlet apparatus. The evaluation of the phytochemical constituents of E. hirta and acute toxicity (to ascertain the safety of using the phytomedicine over a short period of time) was carried out. The antiulcer and gastroprotective effects of crude extract of E. hirta combined with honey in rats were evaluated. The study model using 0.6 M HCl model of ulceration was used to evaluate the antiulcer and gastroprotective activities of the phytomedicine. The soxhlet extraction of E. hirta gave a yield of 54.5 g of crude extract (5.45%). Phytochemical screening of E. hirta showed that the extract contains alkaloids, tannins, saponins, glycosides, flavonoids, and unsaturated steroids. Acute toxicity studies showed that LD₅₀ was greater than 5000 mg/kg. The study showed that the crude extract of E. hirta at 200 mg/kg when administered alone had 54% inhibition of ulceration while when administered together with honey increased to 94% inhibition of ulceration, but honey alone had 89.47% inhibition of ulceration. This implied that E. hirta when combined with honey had a synergistic effect and enhanced the inhibition of ulceration, and this could be seen by the protection of the gastric mucosa. The study of the phytomedicine E. hirta combined with honey revealed that the phytomedicine has antiulcer activities against 0.6 M HCl-induced gastric ulcer in rats. This therefore validates usage and claim by the Igbo people of the southeastern part of Nigeria that the phytomedicine of E. hirta combined with honey has good antiulcer potential.

中文翻译：

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大戟甲醇提取物和蜂蜜联合对大鼠的抗溃疡作用。

胃溃疡是一种地方性胃肠道疾病，是世界范围内的主要公共卫生问题。当胃中的保护因子（粘液和碳酸氢盐）与攻击性因子（酸和胃蛋白酶）之间不平衡时，就会导致胃溃疡。用索氏提取器用甲醇提取植物提取物大戟大戟（E. hirta）的干粉叶和茎（1000 g）。的植物化学成分的评价E.古草和急性毒性（以确定使用过的短时间内的植物药的安全性）中的溶液中进行。hir。hirta的粗提取物的抗溃疡和胃保护作用。评价与蜂蜜合用的大鼠。使用0.6 M HCl溃疡模型的研究模型评估了该植物药的抗溃疡和胃保护活性。希尔氏大肠杆菌的索氏提取法得到54.5g的粗提物（5.45％）。的植物化学物质的筛选E.古草表明，所述提取物含有生物碱，丹宁，皂甙，苷，类黄酮，和不饱和的类固醇。急性毒性研究表明，LD ₅₀大于5000 mg / kg。研究表明，E。hirta的粗提物当单独服用200 mg / kg时，对溃疡的抑制作用为54％，当与蜂蜜一起服用时，对溃疡的抑制作用达到94％，但是单独服用蜂蜜对溃疡的抑制率为89.47％。这暗示了当与蜂蜜联合使用时，平肠埃希氏菌具有协同作用并增强了对溃疡的抑制作用，这可以通过保护胃粘膜看到。植物药E. hirta与蜂蜜结合的研究表明，植物药对大鼠的0.6 M HCl诱导的胃溃疡具有抗溃疡活性。因此，这证实了尼日利亚东南部伊博人的使用并声称埃希氏菌的植物药与蜂蜜合用具有良好的抗溃疡作用。