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Self-Assembling Peptide EAK16 and RADA16 Nanofiber Scaffold Hydrogel
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-11-20 , DOI: 10.1021/acs.chemrev.0c00690 Febrizio Gelain 1, 2 , Zhongli Luo 3 , Shuguang Zhang 4
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-11-20 , DOI: 10.1021/acs.chemrev.0c00690 Febrizio Gelain 1, 2 , Zhongli Luo 3 , Shuguang Zhang 4
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Short peptides are ubiquitous in nature. They are found as hormones, pheromones, antibacterial and antifungal agents in innate immunity systems, toxins, and pesticides. But no one seriously considered that peptides could be useful as scaffold hydrogel materials. There has been a significant change since 1990 after the discovery of an ionic self-complementary peptide as a very interesting repeating segment in a yeast protein. It is now recognized that self-assembling peptides made from 20 natural amino acids have real material properties. Currently, many diverse applications have been developed from these simple and designer self-assembling peptide scaffold hydrogels and are commercially available. Examples include: (1) real 3D tissue cell cultures of diverse tissue cells and various stem cells, (2) reparative and regenerative medicine as well as tissue engineering, (3) 3D tissue printing, (4) sustained releases of small molecules, growth factors, and monoclonal antibodies, and (5) accelerated wound healings of skin and diabetic ulcers as well as instant hemostatic applications in surgery. Self-assembling peptide nanobiotechnology will likely continue to expand in many directions in the coming years.
中文翻译：
自组装肽EAK16和RADA16纳米纤维支架水凝胶
短肽本质上是普遍存在的。它们被发现是先天免疫系统中的激素，信息素，抗菌剂和抗真菌剂，毒素和杀虫剂。但是没有人认真考虑过肽可以用作支架水凝胶材料。自从1990年发现离子自互补肽作为酵母蛋白中非常有趣的重复片段以来，发生了重大变化。现在已经认识到，由20种天然氨基酸制成的自组装肽具有真实的材料特性。当前，已经从这些简单且设计者自组装的肽支架水凝胶开发了许多不同的应用，并且可商购。示例包括：（1）各种组织细胞和各种干细胞的真实3D组织细胞培养，（2）修复和再生医学以及组织工程，（3）3D组织打印，（4）持续释放小分子，生长因子和单克隆抗体，以及（5）加速皮肤和糖尿病性溃疡的伤口愈合作为外科手术中的即时止血应用。在未来几年中，自组装肽纳米生物技术将可能继续向许多方向发展。
更新日期：2020-12-23
中文翻译：
自组装肽EAK16和RADA16纳米纤维支架水凝胶
短肽本质上是普遍存在的。它们被发现是先天免疫系统中的激素，信息素，抗菌剂和抗真菌剂，毒素和杀虫剂。但是没有人认真考虑过肽可以用作支架水凝胶材料。自从1990年发现离子自互补肽作为酵母蛋白中非常有趣的重复片段以来，发生了重大变化。现在已经认识到，由20种天然氨基酸制成的自组装肽具有真实的材料特性。当前，已经从这些简单且设计者自组装的肽支架水凝胶开发了许多不同的应用，并且可商购。示例包括：（1）各种组织细胞和各种干细胞的真实3D组织细胞培养，（2）修复和再生医学以及组织工程，（3）3D组织打印，（4）持续释放小分子，生长因子和单克隆抗体，以及（5）加速皮肤和糖尿病性溃疡的伤口愈合作为外科手术中的即时止血应用。在未来几年中，自组装肽纳米生物技术将可能继续向许多方向发展。
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