Photocurable Hyperbranched Polymer Medical Glue for Water-Resistant Bonding,Biomacromolecules

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Photocurable Hyperbranched Polymer Medical Glue for Water-Resistant Bonding
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-11-20 , DOI: 10.1021/acs.biomac.0c01302
Yifan Zhang ₁ , Xiaojie Li ₁ , Qinfu Zhu ₁ , Wei Wei ₁ , Xiaoya Liu ₁

Affiliation

Medical glue represents a suitable tool to stop wound bleeding, seal wounds, bond tissues, or implant materials. However, the development of a medical glue for durable underwater bonding remains a challenge. Herein, we developed a hydrophobic hyperbranched polymer-based medical glue with water-resistant bonding ability. Specifically, the hyperbranched polythioether (HBPTE) with abundant terminal thiol groups was first prepared through a simple one-pot thiol-Michael polyaddition reaction. Due to the hyperbranched molecular structure, HBPTE is a liquid material under room temperature, thus enabling the manufacturing of a photocurable HBPTE glue by the direct addition of poly(ethylene glycol) dimethacrylate and a photoinitiator without introduction of a solvent. This solventless HBPTE glue exhibited a maximum underwater adhesive strength of 36 kPa on porcine skin compared to only <10 kPa of the commercial fibrin glue and cyanoacrylate glue. Moreover, since the hydrophobic cross-linked network resists penetration of water, the HBPTE glue minimally swelled (2–10%) and could maintain a glass sheet structure bonded together even after 2 weeks underwater. Furthermore, an in vitro cytotoxicity test showed that the HBPTE glue did not leak any cytotoxic substances and allowed for proliferation of L929 cells on its surface. Moreover, hemocompatibility tests indicated that the HBPTE glue was nonhemolytic and did not induce thrombosis. This HBPTE glue exhibited promising characteristics to potentially find use as an underwater soft tissue adhesive or sealant.

中文翻译：

光固化性超支化聚合物医用胶水，用于防水粘结

医用胶水是阻止伤口出血，密封伤口，粘结组织或植入材料的合适工具。但是，开发用于持久水下粘合的医用胶仍然是一个挑战。在这里，我们开发了一种具有防水粘合能力的疏水性超支化聚合物基医用胶。具体而言，首先通过简单的一锅硫醇-迈克尔加成反应制备具有丰富末端硫醇基的超支化聚硫醚（HBPTE）。由于超支化的分子结构，HBPTE在室温下为液态材料，因此可以通过直接添加聚乙二醇二甲基丙烯酸酯和光引发剂而无需引入溶剂来制造可光固化的HBPTE胶。这种无溶剂的HBPTE胶在猪皮肤上的最大水下粘合强度为36 kPa，而市售的纤维蛋白胶和氰基丙烯酸酯胶的粘合力仅为<10 kPa。此外，由于疏水性交联网络可抵抗水的渗透，因此即使在水下2周后，HBPTE胶也只会发生最小程度的溶胀（2-10％），并且可以保持玻璃板结构粘结在一起。此外，体外细胞毒性试验表明，HBPTE胶未泄漏任何细胞毒性物质，并允许L929细胞在其表面增殖。此外，血液相容性测试表明，HBPTE胶具有非溶血性，不会引起血栓形成。这种HBPTE胶具有广阔的应用前景，有望用作水下软组织胶粘剂或密封剂。

更新日期：2020-12-14

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