Advances of Nanoparticles for Leukemia Treatment,ACS Biomaterials Science & Engineering

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Advances of Nanoparticles for Leukemia Treatment
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-11-20 , DOI: 10.1021/acsbiomaterials.0c01040
Jie Shen _{1,

2} , Zhiguo Lu _{1,

2} , Jianze Wang ₁ , Tianlu Zhang ₁ , Jun Yang ₁ , Yan Li ₁ , Guiying Liu ₃ , Xin Zhang ₁

Affiliation

Leukemia is a liquid tumor caused by a hematopoietic stem cell malignant clone, which seriously affects the normal function of the hematopoietic system. Conventional drugs have poor therapeutic effects due to their poor specificity and stability. With the development of nanotechnology, nonviral nanoparticles bring hope for the efficient treatment of leukemia. Nanoparticles are easily modified. They can be designed to target lesion sites and control drug release. Thereby, nanoparticles can improve the effects of drugs and reduce side effects. This review mainly focuses on and summarizes the current research progress of nanoparticles to deliver different leukemia therapeutic drugs, as to demonstrate the potential of nanoparticles in leukemia treatment.

中文翻译：

纳米颗粒治疗白血病的研究进展

白血病是由造血干细胞恶性克隆引起的液体肿瘤，严重影响造血系统的正常功能。常规药物由于其特异性和稳定性差而具有较差的治疗效果。随着纳米技术的发展，非病毒纳米颗粒为有效治疗白血病带来了希望。纳米粒子易于修饰。可将它们设计为靶向病变部位并控制药物释放。因此，纳米颗粒可以改善药物的作用并减少副作用。这篇综述主要着眼于并总结了纳米颗粒提供不同的白血病治疗药物的当前研究进展，以证明纳米颗粒在白血病治疗中的潜力。

更新日期：2020-12-14

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