Nanobioconjugates: Weapons against Antibacterial Resistance,ACS Applied Bio Materials

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Nanobioconjugates: Weapons against Antibacterial Resistance
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-11-20 , DOI: 10.1021/acsabm.0c01107
Puja Prasad ₁ , Shalini Gupta ₁

Affiliation

The increase in drug resistance in pathogenic bacteria is emerging as a global threat as we swiftly edge toward the postantibiotic era. Nanobioconjugates have gained tremendous attention to treat multidrug-resistant (MDR) bacteria and biofilms due to their tunable physicochemical properties, drug targeting ability, enhanced uptake, and alternate mechanisms of drug action. In this review, we highlight the recent advances made in the use of nanobioconjugates to combat antibacterial resistance and provide crucial insights for designing nanomaterials that can serve as antibacterial agents for nanotherapeutics, nanocargos for targeted antibiotic delivery, or both. Also discussed are different strategies for treating robust biofilms formed by bacteria.

中文翻译：

纳米生物偶联物：对抗细菌耐药性的武器

随着我们迅速迈向后抗生素时代，病原菌耐药性的增加正在成为一种全球威胁。纳米生物偶联物因其可调节的物理化学性质、药物靶向能力、增强的吸收和药物作用的替代机制而在治疗多重耐药 (MDR) 细菌和生物膜方面获得了极大的关注。在这篇综述中，我们重点介绍了使用纳米生物偶联物对抗细菌耐药性的最新进展，并为设计可用作纳米治疗的抗菌剂、用于靶向抗生素递送的纳米货物或两者兼有的纳米材料提供了重要的见解。还讨论了处理由细菌形成的坚固生物膜的不同策略。

更新日期：2020-12-21

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