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NIR-II Fluorescence Imaging-Guided Photothermal Therapy with Amphiphilic Polypeptide Nanoparticles Encapsulating Organic NIR-II Dye
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-11-19 , DOI: 10.1021/acsabm.0c01218 Quan Cheng 1 , Tuanwei Li 1 , Youliang Tian 1 , Huiping Dang 1 , Hongyun Qian 1 , Changchang Teng 1 , Kai Xie 1 , Lifeng Yan 1
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-11-19 , DOI: 10.1021/acsabm.0c01218 Quan Cheng 1 , Tuanwei Li 1 , Youliang Tian 1 , Huiping Dang 1 , Hongyun Qian 1 , Changchang Teng 1 , Kai Xie 1 , Lifeng Yan 1
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NIR-II fluorescence imaging-guided photothermal therapy is a potential tumor therapeutic that has exhibited accurate diagnosis and noninvasive therapy of tumors. Here, we developed an organic macromolecular nanoparticle (PFD) by encapsulating a fluorophore with an amphiphilic polypeptide. The PFD nanoparticle presented a uniform size of 70 nm with a slightly negative charge and exhibited superior photothermal conversion efficiency (40.69%), thermal imaging ability, and considerable photothermal stability. The PFD nanoparticle could accumulate at the tumor site by an enhanced penetration and retention effect and exhibited satisfactory fluorescence imaging and prominent photothermal inhibition effect. In vivo experiments demonstrated that PFD nanoparticles exhibited a prominent photothermal inhibition effect against the tumor. Meanwhile, the therapeutic procedure was monitored by both NIR-II fluorescence and infrared thermal imaging, which demonstrated that the PFD nanoparticles have a potential application in imaging-guided photothermal therapy of tumors.
中文翻译：
用包裹有机 NIR-II 染料的两亲多肽纳米颗粒进行 NIR-II 荧光成像引导的光热治疗
NIR-II荧光成像引导的光热疗法是一种潜在的肿瘤治疗方法，已表现出对肿瘤的准确诊断和无创治疗。在这里，我们通过用两亲多肽封装荧光团开发了一种有机大分子纳米颗粒 (PFD)。PFD 纳米粒子呈现均匀的 70 nm 尺寸，带有轻微的负电荷，并表现出优异的光热转换效率 (40.69%)、热成像能力和相当大的光热稳定性。PFD纳米粒子可以通过增强的穿透和滞留效应在肿瘤部位聚集，并表现出令人满意的荧光成像和显着的光热抑制作用。体内实验表明，PFD纳米粒子对肿瘤表现出显着的光热抑制作用。同时，
更新日期：2020-12-21
中文翻译：
用包裹有机 NIR-II 染料的两亲多肽纳米颗粒进行 NIR-II 荧光成像引导的光热治疗
NIR-II荧光成像引导的光热疗法是一种潜在的肿瘤治疗方法，已表现出对肿瘤的准确诊断和无创治疗。在这里，我们通过用两亲多肽封装荧光团开发了一种有机大分子纳米颗粒 (PFD)。PFD 纳米粒子呈现均匀的 70 nm 尺寸，带有轻微的负电荷，并表现出优异的光热转换效率 (40.69%)、热成像能力和相当大的光热稳定性。PFD纳米粒子可以通过增强的穿透和滞留效应在肿瘤部位聚集，并表现出令人满意的荧光成像和显着的光热抑制作用。体内实验表明，PFD纳米粒子对肿瘤表现出显着的光热抑制作用。同时，
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