A highly efficient synthetic route to polysubstituted 2H-chromenes was developed utilizing a domino O-alkylation/intramolecular Horner–Wadsworth–Emmons (HWE) olefination of diarylmethylphosphonates, which were readily accessed via Lewis acid mediated one-pot three-component coupling of aldehydes, phenols, and triethyl phosphite.

中文翻译：

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通过Domino [4 + 2]环形通道轻松访问3,4-二取代的2H-Chromenes

利用二芳基甲基膦酸酯的多米诺骨烷基O-烷基化/分子内霍纳-沃兹沃思-埃蒙斯（HWE）烯化反应，开发了一种高效的多取代2 H-色烯合成路线，可通过路易斯酸介导的一锅三元醛偶联反应轻松获得，酚和亚磷酸三乙酯。