The multifaceted role of TRAIL signaling in cancer and immunity,The FEBS Journal

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The multifaceted role of TRAIL signaling in cancer and immunity
The FEBS Journal ( IF 5.5 ) Pub Date : 2020-11-20 , DOI: 10.1111/febs.15637
Ludmila Cardoso Alves ₁ , Nadia Corazza ₁ , Olivier Micheau ₂ , Philippe Krebs ₁

Affiliation

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can lead to the induction of apoptosis in tumor or infected cells. However, activation of TRAIL signaling may also trigger nonapoptotic pathways in cancer and in nontransformed cells, that is, immune cells. Here, we review the current knowledge on noncanonical TRAIL signaling. The biological outcomes of TRAIL signaling in immune and malignant cells are presented and explained, with a focus on the role of TRAIL for natural killer (NK) cell function. Furthermore, we highlight the technical difficulties in dissecting the precise molecular mechanisms involved in the switch between apoptotic and nonapoptotic TRAIL signaling. Finally, we discuss the consequences thereof for a therapeutic manipulation of TRAIL in cancer and possible approaches to bypass these difficulties.

中文翻译：

TRAIL 信号在癌症和免疫中的多方面作用

肿瘤坏死因子 (TNF) 相关的凋亡诱导配体 (TRAIL) 是 TNF 超家族的成员，可导致诱导肿瘤或受感染细胞凋亡。然而，TRAIL 信号的激活也可能触发癌症和非转化细胞（即免疫细胞）中的非凋亡途径。在这里，我们回顾了当前关于非规范 TRAIL 信号的知识。介绍和解释了 TRAIL 信号在免疫和恶性细胞中的生物学结果，重点是 TRAIL 在自然杀伤 (NK) 细胞功能中的作用。此外，我们强调了剖析凋亡和非凋亡 TRAIL 信号传导之间转换所涉及的精确分子机制的技术难点。最后，

更新日期：2020-11-20

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