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Graph theory analysis reveals premature ejaculation is a brain disorder with altered structural connectivity and depressive symptom: A DTI‐based connectome study
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-11-20 , DOI: 10.1111/ejn.15048 Jianhuai Chen 1 , Jie Yang 2 , Ziliang Xiang 1 , Xinfei Huang 1 , Chao Lu 3 , Shaowei Liu 3 , Yun Chen 1 , Jun Hu 4
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-11-20 , DOI: 10.1111/ejn.15048 Jianhuai Chen 1 , Jie Yang 2 , Ziliang Xiang 1 , Xinfei Huang 1 , Chao Lu 3 , Shaowei Liu 3 , Yun Chen 1 , Jun Hu 4
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Recent research has shown that premature ejaculation (PE) is associated with negative psychological effects (e.g., depression) and the decline of control over ejaculation is accompanied by structural and functional abnormalities in specific brain areas and connections. However, little is known about the alterations of topological organization in the brain network of patients with PE and its relationship with depressive symptom. We acquired diffusion tensor images, sexual function and depression assessment in 16 lifelong PE patients with depressive symptom, 16 lifelong PE patients without depression and 32 age‐ and education‐matched healthy controls (HC). The differences in nodal centrality and different hub regions among the three groups were compared. Correlation analyses were conducted between the nodal centrality of brain regions displaying significant group differences and the clinical parameters of PE patients. PE patients with depression had increased nodal degree in the right middle frontal gyrus (orbital part) (ORBmid.R) (survived FDR‐correction) compared with HC and PE without depression. PE patients with depression also had increased nodal degree in the left and right posterior cingulate gyrus (PCG.L; PCG.R) compared with HC. In addition, PE with depression had increased nodal betweenness in ORBmid.R compared with HC and PE without depression. Moreover PE with depression had decreased nodal participation in the right rolandic operculum (ROL.R), postcentral gyrus (PoCG.R) and supramarginal gyrus (SMG.R) compared with HC, and had decreased nodal participation in ROL.R and the right inferior parietal gyrus (IPL.R) compared with PE without depression, while PE without depression had increased nodal participation in the left precuneus (PCUN.L) compared with HC. The degree and betweenness of ORBmid.R were positively correlated with the total scores of Beck depression inventory (BDI) while the participation of IPL.R had a negative association with the total scores of BDI. Different hubs were found among PE patients with and without depression and HC based on nodal degree, betweenness and participation; however, no significant group differences were found in the frequency distribution of high‐degree hubs, high‐betweenness hubs, provincial hubs and connector hubs. These findings demonstrated that PE was a brain disorder with altered structural connectivity pattern of brain network and depressive symptom, which suggested that altered structural connectivities of the fronto‐cingulate‐parietal control network were core neurobiological features associated with PE and depression. Together, these alterations could prove helpful for understanding the pathophysiological mechanisms of PE in depression.
中文翻译：
图论分析表明，早泄是一种脑部疾病，具有改变的结构连通性和抑郁症状：一项基于DTI的连接组研究
最近的研究表明，早泄（PE）与负面的心理影响（例如抑郁）相关，而对射精的控制能力下降则伴随着特定大脑区域和连接中的结构和功能异常。然而，关于PE患者脑网络中拓扑结构的变化及其与抑郁症状的关系知之甚少。我们获得了16例有抑郁症状的终身PE患者，16例无抑郁的终身PE患者以及32例年龄和教育程度相匹配的健康对照（HC）的扩散张量图像，性功能和抑郁评估。比较了三组之间的节点中心性差异和不同的枢纽区域。在显示明显组差异的大脑区域的结节中心与PE患者的临床参数之间进行了相关分析。与无抑郁症的HC和PE相比，患有抑郁症的PE患者右中额回（眼眶部分）（ORBmid.R）（幸存的FDR校正）的淋巴结度增加。与HC相比，患有抑郁症的PE患者左后扣带回和右后扣带回（PCG.L; PCG.R）的淋巴结程度也有所增加。另外，与不伴抑郁的HC和PE相比，伴抑郁的PE在ORBmid.R中的淋巴结间隔增加。此外，与HC相比，伴有抑郁症的PE减少了对右手land盖（ROL.R），中央后回（PoCG.R）和超上回（SMG.R）的淋巴结参与，并减少了对ROL的淋巴结参与。与不伴抑郁的PE相比，R和右下壁顶回（IPL.R）与不伴抑郁的PE相比，对左前突（PCUN.L）的淋巴结参与性增加。ORBmid.R的程度和相互关系与贝克抑郁量表（BDI）的总得分呈正相关，而IPL.R的参与度与BDI的总得分呈负相关。根据淋巴结的程度，中间程度和参与程度，在患有和不患有抑郁症和HC的PE患者中发现了不同的枢纽。但是，在高集线器，高中间集线器，省集线器和连接器集线器的频率分布中，没有发现显着的组差异。这些发现表明，PE是一种脑部疾病，大脑网络的结构连接方式发生了改变，并伴有抑郁症状，这表明额扣带回顶壁控制网络的结构连接性的改变是与PE和抑郁症相关的核心神经生物学特征。总之，这些改变可能有助于理解抑郁症中PE的病理生理机制。
更新日期：2020-11-20
中文翻译：
图论分析表明，早泄是一种脑部疾病，具有改变的结构连通性和抑郁症状：一项基于DTI的连接组研究
最近的研究表明，早泄（PE）与负面的心理影响（例如抑郁）相关，而对射精的控制能力下降则伴随着特定大脑区域和连接中的结构和功能异常。然而，关于PE患者脑网络中拓扑结构的变化及其与抑郁症状的关系知之甚少。我们获得了16例有抑郁症状的终身PE患者，16例无抑郁的终身PE患者以及32例年龄和教育程度相匹配的健康对照（HC）的扩散张量图像，性功能和抑郁评估。比较了三组之间的节点中心性差异和不同的枢纽区域。在显示明显组差异的大脑区域的结节中心与PE患者的临床参数之间进行了相关分析。与无抑郁症的HC和PE相比，患有抑郁症的PE患者右中额回（眼眶部分）（ORBmid.R）（幸存的FDR校正）的淋巴结度增加。与HC相比，患有抑郁症的PE患者左后扣带回和右后扣带回（PCG.L; PCG.R）的淋巴结程度也有所增加。另外，与不伴抑郁的HC和PE相比，伴抑郁的PE在ORBmid.R中的淋巴结间隔增加。此外，与HC相比，伴有抑郁症的PE减少了对右手land盖（ROL.R），中央后回（PoCG.R）和超上回（SMG.R）的淋巴结参与，并减少了对ROL的淋巴结参与。与不伴抑郁的PE相比，R和右下壁顶回（IPL.R）与不伴抑郁的PE相比，对左前突（PCUN.L）的淋巴结参与性增加。ORBmid.R的程度和相互关系与贝克抑郁量表（BDI）的总得分呈正相关，而IPL.R的参与度与BDI的总得分呈负相关。根据淋巴结的程度，中间程度和参与程度，在患有和不患有抑郁症和HC的PE患者中发现了不同的枢纽。但是，在高集线器，高中间集线器，省集线器和连接器集线器的频率分布中，没有发现显着的组差异。这些发现表明，PE是一种脑部疾病，大脑网络的结构连接方式发生了改变，并伴有抑郁症状，这表明额扣带回顶壁控制网络的结构连接性的改变是与PE和抑郁症相关的核心神经生物学特征。总之，这些改变可能有助于理解抑郁症中PE的病理生理机制。
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