In this study, a water-soluble and upconverting PSI_OAm-modified Sr₂LaF₇: 20%Yb³⁺/6%Er³⁺ (abbreviated as SLF@PSI_OAm) with a small size of ~10 nm was designed and prepared for bioimaging. The optimum and intensest red-light emission at 640–690 nm was modulated via 6% Er³⁺ doped under irradiation at 980 nm, and the ratio of red and green emission intensely (I_red/I_green) was as high as 1.378. Interestingly, biological experimental results showed that SLF@PSI_OAm with low toxicity and excellent cell/tissues permeability could not only be applied to cells imaging, but also successfully visualize lipid-rich tissues in living zebrafish. Therefore, it can be anticipated that the as-prepared material would be a potential tool for upconversion fluorescence bioimaging.

在本研究中，设计并制备了水溶性且上转换的PSI _OAm修饰的Sr ₂ LaF ₇：20％Yb ³⁺ / 6％Er ³⁺（缩写为SLF @ PSI _OAm），尺寸约为10 nm。用于生物成像。通过在980 nm的辐射下掺入6％的Er ³⁺，可以调节640-690 nm的最佳和最强的红光发射，并且红色和绿色的发射强度之比（I _red / I _green）高达1.378。有趣的是，生物学实验结果表明SLF @ PSI _OAm低毒性和优异的细胞/组织渗透性不仅可以用于细胞成像，而且还可以成功地观察活斑马鱼中富含脂质的组织。因此，可以预料，所制备的材料将是用于上转换荧光生物成像的潜在工具。