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A cross sectional assessment of nutrient intake and the association of the inflammatory properties of nutrients and foods with symptom severity, in a large cohort from the UK Multiple Sclerosis Registry.
Nutrition Research ( IF 3.4 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.nutres.2020.11.006 Shelly Coe 1 , Thanasis G Tektonidis 2 , Clare Coverdale 3 , Sarah Penny 3 , Johnny Collett 4 , Bernard T Y Chu 3 , Hooshang Izadi 5 , Rod Middleton 6 , Helen Dawes 7
Nutrition Research ( IF 3.4 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.nutres.2020.11.006 Shelly Coe 1 , Thanasis G Tektonidis 2 , Clare Coverdale 3 , Sarah Penny 3 , Johnny Collett 4 , Bernard T Y Chu 3 , Hooshang Izadi 5 , Rod Middleton 6 , Helen Dawes 7
Affiliation
To assess the intake of nutrients in people with multiple sclerosis (pwMS) compared to a control population, and to assess the pro/ anti-inflammatory properties of nutrients/ foods and their relationships with fatigue and quality of life. This was a cross sectional study in which 2410 pwMS (686 men; 1721 women, 3 n/a, mean age 53 (11 years)) provided dietary data using a food frequency questionnaire that was hosted on the MS Register for a period of 3 months and this was compared to a cohort of 24,852 controls (11,250 male, 13,602 female, mean age 59 years). Consent was implied by anonymously filling out the questionnaire. A Wilcoxon test was used to compare intake between pwMS and controls, and a bivariate analyses followed by chi2 test were undertaken to identify significance and the strength of the relationship between pro/anti-inflammatory dietary factors and fatigue and EQ-5D. Compared to controls, all nutrients were significantly lower in the MS group (P < .05). Bivariate associations showed a significant correlation between consuming fish and lower clinical fatigue (χ2(1) = 4.221, P< .05), with a very low association (φ (phi) = -0.051, P = .04. Positive health outcomes on the EQ-5D measures were associated with higher carotene, magnesium oily fish and fruits and vegetable and sodium consumption (P < .05). Fiber, red meat, and saturated fat (women only) consumption was associated with worse outcomes on the EQ-5D measures (P < .05). pwMS have different dietary intakes compared to controls, and this may be associated with worse symptoms.
中文翻译：
在来自英国多发性硬化症登记处的一个大型队列中，对营养素摄入量的横断面评估以及营养素和食物的炎症特性与症状严重程度的关联。
与对照人群相比，评估多发性硬化症 (pwMS) 患者的营养素摄入量，并评估营养素/食物的促/抗炎特性及其与疲劳和生活质量的关系。这是一项横断面研究，其中 2410 名 pwMS（686 名男性；1721 名女性，3 名不适用，平均年龄 53（11 岁））使用在 MS 登记册上托管的食物频率问卷提供了饮食数据，该问卷在 3月，并将其与 24,852 名对照组（11,250 名男性，13,602 名女性，平均年龄 59 岁）进行比较。匿名填写问卷即表示同意。Wilcoxon 检验用于比较 pwMS 和对照之间的摄入量，进行双变量分析，然后进行 chi2 检验，以确定促/抗炎饮食因素与疲劳和 EQ-5D 之间关系的重要性和强度。与对照组相比，MS 组的所有营养素均显着降低（P < .05）。双变量关联显示食用鱼与较低的临床疲劳之间存在显着相关性（χ2(1) = 4.221, P < .05），关联性非常低（φ (phi) = -0.051, P = .04。积极的健康结果） EQ-5D 测量与较高的胡萝卜素、镁油性鱼类、水果和蔬菜以及钠的摄入量相关（P < .05）。纤维、红肉和饱和脂肪（仅限女性）的摄入量与 EQ-的较差结果相关。 5D 测量值 (P < .05)。与对照组相比，pwMS 具有不同的膳食摄入量，
更新日期：2021-01-01
中文翻译：
在来自英国多发性硬化症登记处的一个大型队列中，对营养素摄入量的横断面评估以及营养素和食物的炎症特性与症状严重程度的关联。
与对照人群相比，评估多发性硬化症 (pwMS) 患者的营养素摄入量，并评估营养素/食物的促/抗炎特性及其与疲劳和生活质量的关系。这是一项横断面研究，其中 2410 名 pwMS（686 名男性；1721 名女性，3 名不适用，平均年龄 53（11 岁））使用在 MS 登记册上托管的食物频率问卷提供了饮食数据，该问卷在 3月，并将其与 24,852 名对照组（11,250 名男性，13,602 名女性，平均年龄 59 岁）进行比较。匿名填写问卷即表示同意。Wilcoxon 检验用于比较 pwMS 和对照之间的摄入量，进行双变量分析，然后进行 chi2 检验，以确定促/抗炎饮食因素与疲劳和 EQ-5D 之间关系的重要性和强度。与对照组相比，MS 组的所有营养素均显着降低（P < .05）。双变量关联显示食用鱼与较低的临床疲劳之间存在显着相关性（χ2(1) = 4.221, P < .05），关联性非常低（φ (phi) = -0.051, P = .04。积极的健康结果） EQ-5D 测量与较高的胡萝卜素、镁油性鱼类、水果和蔬菜以及钠的摄入量相关（P < .05）。纤维、红肉和饱和脂肪（仅限女性）的摄入量与 EQ-的较差结果相关。 5D 测量值 (P < .05)。与对照组相比，pwMS 具有不同的膳食摄入量，
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