The transient receptor potential (TRP) channels constitute a superfamily of large ion channels that are activated by a wide range of chemical, mechanical and thermal stimuli. TRP channels with temperature sensitivity are called thermo-TRPs. They are involved in diverse physiological functions through their detection of external environmental temperature and internal body temperature. Each thermo-TRP has its own characteristic temperature threshold for activation. As a group, they cover temperatures ranging from cold to nociceptive high temperatures. Recently, many studies have identified the functions of thermo-TRPs residing in deep organs where they are exposed to body temperature. Importantly, temperature thresholds of thermo-TRPs can be regulated by physiological factors enabling their function at relatively constant body temperature. Moreover, several thermo-TRPs are reportedly engaged in body temperature regulation. This review will summarize the current understanding of thermo-TRPs, including their roles in thermosensation and functional regulation of physiological responses at body temperature and the regulation of body temperature.

瞬时受体电位 (TRP) 通道构成大离子通道的超家族，可被各种化学、机械和热刺激激活。具有温度敏感性的 TRP 通道称为热 TRP。它们通过检测外部环境温度和内部体温参与多种生理功能。每个thermo-TRP 都有其自身的激活特征温度阈值。作为一个群体，它们涵盖了从寒冷到伤害性高温的温度。最近，许多研究已经确定了存在于暴露于体温的深部器官中的热-TRP 的功能。重要的是，热-TRP 的温度阈值可以通过生理因素进行调节，使其能够在相对恒定的体温下发挥作用。而且，据报道，一些热-TRP 参与体温调节。本综述将总结目前对热-TRPs 的理解，包括它们在体温下生理反应的热感觉和功能调节以及体温调节中的作用。