The uncontrolled parenchymatic bleeding is still a cause of serious complications in surgery and require new effective hemostatic materials. In recent years, numerous chitosan-based materials have been intensively studied for parenchymatic bleeding control but still require to increased safety and effectiveness. The current research is devoted to new hemostatic materials made of natural polymer (chitosan) developed using electrospinning and microwave-assisted methods. Hemostatic performance, biocompatibility, degradation, and in-vivo effectiveness were studied to assess functional properties of new materials. Chitosan-based agents demonstrated considerable hemostatic performance, moderate biodegradation pace and high biocompatibility in vitro. Using the electrospinning-made chitosan-copolymer significantly improved in vivo biocompatibility and degradation of Chitosan-based agents that provides opportunities for its implementation for visceral bleeding management. Chitosan aerogel could be effectively applied in hemostatic patch development due to high antibacterial activity but it is not recommended for visceral application due to moderate inflammatory effect and slow degradation.

无法控制的实质性出血仍然是外科手术中严重并发症的原因，需要新的有效止血材料。近年来，已经广泛研究了许多基于壳聚糖的材料以控制实质性出血，但是仍然需要提高安全性和有效性。当前的研究致力于使用静电纺丝和微波辅助方法开发的由天然聚合物（壳聚糖）制成的新型止血材料。研究了止血性能，生物相容性，降解和体内有效性，以评估新材料的功能特性。基于壳聚糖的药物在体外表现出可观的止血性能，适度的生物降解速度和高生物相容性。使用静电纺丝制成的壳聚糖共聚物可显着改善基于壳聚糖的药物的体内生物相容性和降解性，这为其实施内脏出血管理提供了机会。壳聚糖气凝胶由于具有很高的抗菌活性，因此可以有效地用于止血贴剂的开发，但由于中等的炎症作用和缓慢的降解作用，不建议用于内脏。