This study introduces a mesoporous magnetic nano-system for the delivery of apigenin (API). A targeted therapeutic drug delivery system was prepared based on Fe₂O₃/Fe₃O₄@mSiO₂-HA nanocomposites. Magnetic Fe₂O₃/Fe₃O₄ heterogeneous nanoparticles were first prepared via the rapid-combustion process. The effects of solvent type, solvent volume, calcination temperature, and calcination time on the crystal size and magnetism of the Fe₂O₃/Fe₃O₄ heterogeneous nanoparticles were investigated. The mesoporous silica shell was deposited on the Fe₂O₃/Fe₃O₄ heterogeneous nanoparticles using an improved Stöber method. HA was exploited as the targeting ligand. The specific surface area of the Fe₂O₃/Fe₃O₄@mSiO₂ nanocomposites was 369.6 m²/g, which is 19 times higher than that of the magnetic Fe₂O₃/Fe₃O₄ heterogeneous nanoparticle cores. Drug release properties from the Fe₂O₃/Fe₃O₄@mSiO₂-HA nanocomposites were studied, and the result showed that API-loaded nano-system had sustained release effect. Prussian blue staining and electrochemical performance variation showed that an external magnetic field facilitated cell uptake of Fe₂O₃/Fe₃O₄@mSiO₂-HA nanocomposites. MTT assays showed that the cell inhibition effect of API-Fe₂O₃/Fe₃O₄@mSiO₂-HA was stronger than that of free API at the same drug dose under a magnetic field and Fe₂O₃/Fe₃O₄@mSiO₂-HA nanocomposites showed good biocompatibility. Fluorescence imaging, flow cytometry, western blot, reactive oxygen species (ROS), Superoxide dismutase (SOD) and malondialdehyde (MDA) kits verified that the enhanced therapeutic action was due to the promotion of apoptosis, lipid peroxidation, and ferroptosis. The magnetic nano-system (Fe₂O₃/Fe₃O₄@mSiO₂-HA) showed good magnetic targeting and active hyaluronic acid targeting, and has the potential to provide a targeted delivery platform for many antitumor drugs.

这项研究介绍了一种介孔磁性纳米系统，用于输送芹菜素（API）。基于Fe ₂ O ₃ / Fe ₃ O ₄ @mSiO ₂ -HA纳米复合材料制备了靶向治疗药物递送系统。首先通过快速燃烧过程制备磁性Fe ₂ O ₃ / Fe ₃ O ₄异质纳米颗粒。溶剂类型，溶剂量，煅烧温度和煅烧时间对Fe ₂ O ₃ / Fe ₃ O ₄的晶体尺寸和磁性的影响研究了异质纳米颗粒。使用改进的Stöber方法将中孔二氧化硅壳沉积在Fe ₂ O ₃ / Fe ₃ O ₄异质纳米颗粒上。HA被用作靶向配体。Fe ₂ O ₃ / Fe ₃ O ₄ @mSiO ₂纳米复合材料的比表面积为369.6 m ² / g，是磁性Fe ₂ O ₃ / Fe ₃ O ₄异质纳米颗粒核的比表面积的19倍。Fe ₂ O _3的药物释放特性对/ Fe ₃ O ₄ @mSiO ₂ -HA纳米复合材料进行了研究，结果表明，载有API的纳米体系具有缓释作用。普鲁士蓝染色和电化学性能变化表明，外部磁场有助于细胞吸收Fe ₂ O ₃ / Fe ₃ O ₄ @mSiO ₂ -HA纳米复合材料。MTT分析表明，在磁场和Fe ₂ O ₃相同剂量下，API-Fe ₂ O ₃ / Fe ₃ O ₄ @mSiO ₂ -HA的细胞抑制作用强于游离API。/ Fe ₃ O ₄ @mSiO ₂ -HA纳米复合材料表现出良好的生物相容性。荧光成像，流式细胞仪，蛋白质印迹，活性氧（ROS），超氧化物歧化酶（SOD）和丙二醛（MDA）试剂盒证实，增强的治疗作用归因于细胞凋亡，脂质过氧化作用和肥大症。磁性纳米系统（Fe ₂ O ₃ / Fe ₃ O ₄ @mSiO ₂ -HA）表现出良好的磁性靶向性和活性透明质酸靶向性，并有潜力为许多抗肿瘤药物提供靶向递送平台。