Chemical warfare agents (CWAs) are the most feared and unpredictable terrorist weapon that threaten global security. For the issue of human security, it is highly demanded to establish rapid and reliable methods for the detection of CWAs. In this work, a hemicyanine-based colorimetric and off-on fluorescent dual-modal probe for the detection of a nerve agent mimic diethyl cyanophosphonate (DCNP) has been developed. The probe exhibits fast response (<3 min), high selectivity, and excellent sensitivity with a low limit of detection (4.5 nM). More importantly, test strips loaded with the probe can sense DCNP vapor in low concentration and distinguish DCNP vapor from other nerve agent mimics by both naked eyes and fluorescence.

化学战剂（CWA）是威胁全球安全的最令人恐惧和不可预测的恐怖武器。对于人类安全问题，迫切需要建立快速可靠的方法来检测CWA。在这项工作中，已开发出一种基于半花菁的比色和关闭式荧光双峰探针，用于检测神经毒剂模拟氰基膦酸二乙酯（DCNP）。该探针具有快速响应（<3分钟），高选择性和出色的灵敏度以及低检测限（4.5 nM）的特点。更重要的是，装有探针的试纸条可以通过低浓度检测DCNP蒸气，并通过肉眼和荧光将DCNP蒸气与其他神经元模拟物区分开。