当前位置: X-MOL 学术Cortex › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The left prefrontal cortex supports inhibitory processing during semantic memory retrieval
Cortex ( IF 3.6 ) Pub Date : 2020-11-20 , DOI: 10.1016/j.cortex.2020.11.001
Martin Marko 1 , Igor Riečanský 2
Affiliation  

Semantic control refers to a set of neural and cognitive mechanisms that govern semantic processing and retrieval. Neuroimaging studies have indicated that controlled semantic processing engages the left prefrontal cortex (PFC), yet the functional role of the prefrontal activity in semantic control is poorly understood and was therefore addressed in the present study. We used a double-blind randomized controlled experiment, in which participants from three distinct groups received anodal transcranial direct current stimulation (tDCS) over left lateral PFC (n = 40), a control tDCS over temporoparietal cortex (n = 40), or sham stimulation (n = 41), while executing automatic and controlled semantic retrieval tasks as well as additional control tasks assessing working memory and semantic judgement. We demonstrate that anodal tDCS of the left lateral PFC improved inhibition of prepotent semantic associations but had no significant effect on retrieval of habitual associates or switching between retrieval rules. The prefrontal tDCS also enhanced working memory capacity, but this effect did not account for the improved semantic inhibition. The control temporoparietal tDCS did not affect semantic retrieval. Our findings show that semantic inhibition and switching represent distinct components of the semantic control system and indicate that the left lateral PFC is involved in a filtering process that constrains the accessible semantic representations (i.e., a proactive pre-retrieval inhibition) or suppresses already retrieved responses (i.e., a retroactive post-retrieval inhibition). The recognition of such an inhibitory process could inspire novel treatments targeting altered semantic processing.



中文翻译:

左前额叶皮层支持语义记忆检索期间的抑制处理

语义控制是指控制语义处理和检索的一组神经和认知机制。神经影像学研究表明,受控语义处理参与了左前额叶皮层(PFC),但对额叶前活动在语义控制中的功能作用了解甚少,因此在本研究中得到了解决。我们使用了一项双盲随机对照实验,其中来自三个不同组的参与者在左侧PFC上接受了经颅经颅直流电刺激(tDCS)(n  = 40),在颞顶皮质上进行了对照tDCS(n  = 40)或假手术刺激(ñ = 41),同时执行自动和受控的语义检索任务以及评估工作记忆和语义判断的其他控制任务。我们证明,左侧tfc的阳极tDCS改善了对潜在语义关联的抑制,但对习惯性关联的检索或检索规则之间的切换没有显着影响。前额叶tDCS还增强了工作记忆能力,但这种作用并未说明语义抑制的改善。颞颞tDCS控件不影响语义检索。我们的发现表明,语义抑制和切换代表了语义控制系统的不同组成部分,并表明左侧横向PFC参与了约束可访问语义表示(即,主动的检索前抑制)或抑制已经检索到的响应(即追溯的检索后抑制)。这种抑制过程的认识可以激发针对改变的语义处理的新颖治疗方法。

更新日期:2020-12-14
down
wechat
bug