Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic mutations in normal human tissues, and here we discuss their implications for our understanding of tumorigenesis.

中文翻译：

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癌症转化中的正常体细胞突变

基因改变在驱动癌症的发生和进展中发挥着重要作用。然而，在肿瘤发生之前正常细胞中发生的遗传事件仍然未知。最近的研究已经开始绘制正常人体组织中的体细胞突变图谱，在这里我们讨论它们对我们理解肿瘤发生的影响。