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Approaches for determining cardiac bidomain conductivity values: progress and challenges
Medical & Biological Engineering & Computing ( IF 2.6 ) Pub Date : 2020-10-22 , DOI: 10.1007/s11517-020-02272-z
Barbara M Johnston 1 , Peter R Johnston 1
Affiliation  

Modelling the electrical activity of the heart is an important tool for understanding electrical function in various diseases and conduction disorders. Clearly, for model results to be useful, it is necessary to have accurate inputs for the models, in particular the commonly used bidomain model. However, there are only three sets of four experimentally determined conductivity values for cardiac ventricular tissue and these are inconsistent, were measured around 40 years ago, often produce different results in simulations and do not fully represent the three-dimensional anisotropic nature of cardiac tissue. Despite efforts in the intervening years, difficulties associated with making the measurements and also determining the conductivities from the experimental data have not yet been overcome. In this review, we summarise what is known about the conductivity values, as well as progress to date in meeting the challenges associated with both the mathematical modelling and the experimental techniques.



中文翻译:

确定心脏双域电导率值的方法:进展与挑战

模拟心脏的电活动是了解各种疾病和传导障碍中的电功能的重要工具。显然,为了使模型结果有用,必须有准确的模型输入,尤其是常用的双域模型。然而,心脏心室组织只有三组四个实验确定的电导率值,并且这些值不一致,是在大约 40 年前测量的,在模拟中经常产生不同的结果,并且不能完全代表心脏组织的三维各向异性性质。尽管在随后的几年中做出了努力,但与进行测量以及从实验数据确定电导率相关的困难尚未得到克服。在本次审查中,

更新日期:2020-11-21
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