In clinical studies, the effect of heart rate (HR) alone as feedback for maintaining homeostasis cannot be observed. Therefore, in this study, the effect of HR on pulse wave velocity (PWV) was investigated using a simulator without feedback. This was achieved via a one-tube model that simplifies the human arterial system and an arterial tree model similar to the human body, using a cardiovascular simulator. The one-tube model measured the pressure waveform at two measuring points 1.2 m apart, while the arterial tree model measured the pressure waveform in the carotid and femoral arteries. In the one-tube experiment, the effects of HR, mean pressure (MP), and stroke volume (SV) on PWV were independently investigated. PWV was found to increase as HR increased, but was not affected when MP and SV were changed. Further, in the arterial tree model experiment, it was observed that the PWV increased with an increase in HR. The results of this study showed that even in a simulator containing a human arterial model made of silicone material with no human feedback action, changes in HR alone affect the PWV.

中文翻译：

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使用心血管模拟器分析心率与脉搏波速度的相关性

在临床研究中，无法观察到心率 (HR) 单独作为维持体内平衡的反馈的效果。因此，在本研究中，使用没有反馈的模拟器研究 HR 对脉搏波速度 (PWV) 的影响。这是通过使用心血管模拟器简化人体动脉系统的单管模型和类似于人体的动脉树模型来实现的。单管模型在两个相距 1.2 m 的测量点测量压力波形，而动脉树模型测量颈动脉和股动脉的压力波形。在单管实验中，独立研究了 HR、平均压力 (MP) 和每搏输出量 (SV) 对 PWV 的影响。发现 PWV 随着 HR 的增加而增加，但在 MP 和 SV 改变时不受影响。更多，在动脉树模型实验中，观察到PWV随着HR的增加而增加。这项研究的结果表明，即使在包含由硅胶材料制成的人体动脉模型且没有人体反馈作用的模拟器中，仅 HR 的变化就会影响 PWV。