The microwave-assisted syntheses and applications of non-fused single-nitrogen-containing heterocycles,Organic & Biomolecular Chemistry

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The microwave-assisted syntheses and applications of non-fused single-nitrogen-containing heterocycles
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-10-29 , DOI: 10.1039/d0ob01779e
Jay Prakash Soni ₁ , Krishna Sowjanya Chemitikanti , Swanand Vinayak Joshi , Nagula Shankaraiah

Affiliation

Microwave technology has emerged as a great tool for the efficient synthesis of organic compounds and it provides opportunities for chemists to achieve chemical transformations that tend to be challenging using classical approaches. Additionally, N-heterocycles are well-known for their medicinal/biological significance, along with their applications as excellent building blocks in chemical synthesis. The dominance of N-heterocycles in drug molecules and other pharmacological agents makes them attractive scaffolds, which encourages chemists to develop a wide range of strategies towards the greener synthesis and functionalization of these heterocycles. In this regard, we have collated and discussed literature relating to the microwave-assisted synthesis and the modification of non-(benzo)fused single-nitrogen-containing N-heterocycles from the past decade. The role of the microwave technique and its benefits over the conventional approach have also been emphasized in terms of overall reaction efficiency, reaction time, yield, reduced side-product generation, neat and clean reactions, chemo-/regio-/enantio-selectivity, and the use of mild reagents/reaction conditions to achieve the objectives of green and sustainable chemistry.

中文翻译：

非稠合单氮杂环的微波辅助合成及应用

微波技术已成为有效合成有机化合物的重要工具，它为化学家提供了使用经典方法实现化学转化的机会，而这些转化往往具有挑战性。此外，N-杂环化合物以其药用/生物学意义以及它们在化学合成中作为优秀构件的应用而闻名。N-杂环在药物分子和其他药剂中的主导地位使其成为有吸引力的支架，这鼓励化学家开发广泛的策略来实现这些杂环的更绿色合成和功能化。在这方面，我们整理并讨论了过去十年中与微波辅助合成和非（苯并）稠合单含氮 N-杂环的改性有关的文献。在总体反应效率、反应时间、产率、减少的副产物产生、整洁和清洁的反应、化学/区域/对映选择性，以及使用温和的试剂/反应条件来实现绿色和可持续化学的目标。

更新日期：2020-11-19

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