Abstract: Acne is a common skin disease that affect over 80% of adolescents. It is characterized by inflammation of the hair bulb and the attached sebaceous gland. To date, many strategies have been used to treat acne as a function of the disease severity. However, common treatments for acne seem to show several side effects, from local irritation to more serious collateral effects. The use of topical vesicular carriers able to deliver active compounds is currently considered as an excellent approach in the treatment of different skin diseases. Many results in the literature have proven that drug delivery systems are useful in overcoming the toxicity induced by common drug therapies, while maintaining their therapeutic efficacy. Starting from these assumptions, the authors reviewed drug delivery systems already realized for the topical treatment of acne, with a focus on their limitations and advantages over conventional treatment strategies. Although their exact mechanism of permeation is not often completely clear, deformable vesicles seem to be the best solution for obtaining a specific delivery of drugs into the deeper skin layers, with consequent increased local action and minimized collateral effects.

Keywords: targeted therapy, skin, anti-acne drugs, nanocarriers, drug delivery systems


中文翻译：

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纳米囊泡选择性局部递送治疗痤疮的挑战：增强吸收，同时避免毒性


【摘要】：痤疮是一种常见的皮肤病,影响80%以上的青少年。其特征是毛球和附着的皮脂腺发炎。迄今为止，已使用许多策略根据疾病严重程度来治疗痤疮。然而，常见的痤疮治疗方法似乎显示出多种副作用，从局部刺激到更严重的附带影响。使用能够递送活性化合物的局部囊泡载体目前被认为是治疗不同皮肤病的极好方法。文献中的许多结果已经证明，药物递送系统可用于克服常见药物疗法引起的毒性，同时保持其治疗功效。从这些假设出发，作者回顾了已经实现的用于痤疮局部治疗的药物输送系统，重点是它们相对于传统治疗策略的局限性和优点。尽管其确切的渗透机制通常并不完全清楚，但可变形囊泡似乎是将药物特异性输送到更深的皮肤层的最佳解决方案，从而增加局部作用并最大限度地减少附带影响。


关键词:靶向治疗, 皮肤, 抗痤疮药物, 纳米载体, 给药系统