Based on the synergistic effect of Mg2+ and antibacterial peptides to improve the corrosion resistance, antibacterial ability and osteogenic activity of magnesium-based degradable metals,Biomaterials Science

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Based on the synergistic effect of Mg2+ and antibacterial peptides to improve the corrosion resistance, antibacterial ability and osteogenic activity of magnesium-based degradable metals
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-11-19 , DOI: 10.1039/d0bm01584a
Wenhao Zhou _{1,

2,

3,

4} , Jianglong Yan _{5,

6,

7,

8} , Yangyang Li _{5,

6,

7,

8} , Lan Wang _{1,

2,

3,

4} , Lei Jing _{1,

2,

3,

4} , Ming Li _{8,

9,

10,

11,

12} , Sen Yu _{1,

2,

3,

4} , Yan Cheng _{5,

6,

7,

8} , Yufeng Zheng _{6,

8,

13,

14,

15}

Affiliation

To overcome the restricted degradation, poor antiacterial and osteoindctive problems of magnesium and its alloys, this study presented the spinning coating of an antimicrobial peptide (AP)-loaded silk fibroin (SF) composite onto a corrosion-resistant MgO-coated AZ31 Mg alloy via anodization (aMgO) and electrodeposition (eMgO) methods. The composite coatings not only created a smooth and hydrophilic surface, but also obviously improved the corrosion resistance according to the test of corrosion potential and current density. The colonization of E. coli on MgO–AP composite coatings was significantly reduced as compared to the MgO layers, due to the potential synergetic effects of APs and Mg²⁺. Compared with the bare AZ31, the composite coating inhibited the corrosion of the substrate and the release of Mg²⁺, supported the adhesion, spreading and proliferation of osteoblasts, and presented a significantly improved osteogenic differentiation trend. Therefore, the MgO–AP composite coating, which had both antibacterial and bone-promoting abilities, was expected to be applied for surface modification of magnesium alloy implants to solve the clinical problems of bacterial infection and poor osseointegration.

中文翻译：

基于Mg2 +和抗菌肽的协同作用，提高镁基可降解金属的耐蚀性，抗菌能力和成骨活性

为了克服镁及其合金的降解受限，抗微生物和抗骨诱导性差的问题，本研究提出了通过抗微生物剂（AP）负载的丝素蛋白（SF）复合材料的纺丝涂层，该涂层是通过抗腐蚀的MgO涂层的AZ31 Mg合金制成的。阳极氧化（aMgO）和电沉积（eMgO）方法。根据腐蚀电位和电流密度的测试，该复合涂层不仅产生了光滑而亲水的表面，而且还明显改善了其耐腐蚀性。与MgO层相比，在MgO–AP复合涂层上大肠杆菌的定殖显着减少，这是由于AP和Mg ²⁺的潜在协同作用。与裸露的AZ31相比，复合涂层抑制了基体的腐蚀和Mg ²⁺的释放，支持了成骨细胞的粘附，扩散和增殖，并呈现出明显改善的成骨分化趋势。因此，具有抗菌和促进骨骼功能的MgO-AP复合涂层有望用于镁合金植入物的表面改性，以解决细菌感染和骨整合不良的临床问题。

更新日期：2020-12-16

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