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Alizarin-based molecular probes for the detection of hydrogen peroxide and peroxynitrite
Analyst ( IF 3.6 ) Pub Date : 2020-11-13 , DOI: 10.1039/d0an01805h Minglu Li 1, 2, 3, 4 , Peng Lei 1, 2, 3, 4 , Shengmei Song 2, 3, 4, 5 , Shaomin Shuang 1, 2, 3, 4 , Chuan Dong 2, 3, 4, 5
Analyst ( IF 3.6 ) Pub Date : 2020-11-13 , DOI: 10.1039/d0an01805h Minglu Li 1, 2, 3, 4 , Peng Lei 1, 2, 3, 4 , Shengmei Song 2, 3, 4, 5 , Shaomin Shuang 1, 2, 3, 4 , Chuan Dong 2, 3, 4, 5
Affiliation
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Phenol fluorophores are a large family of fluorophores, which have attracted more and more attention in the design of probes. Using the self-assembly of aromatic boronic acid with Alizarin Red S (ARS) and Gallein (GAL), the novel chemosensors ARS–CBA and GAL–CBA were provided for hydrogen peroxide (H2O2), which demonstrated their ability to detect H2O2 with indicator displacement assay (IDA) by colorimetric and electrochemical measurements. After ARS–CBA and GAL–CBA reacted with H2O2, the systems displayed a red-shifted visible color change in aqueous media and off-on electrochemical signals showing generation of phenol. The chemosensor ARS–CBA also had good performance in fluorometric measurements and turn-off fluorescent response indicated removal of aromatic boronic acid. In addition, a designed near-infrared (NIR) dual-modal fluorescent probe alizarin blue S (ABS) was used for peroxynitrite (ONOO−) with a visible colorimetric change in dimethyl sulfoxide (DMSO) and “on–off” fluorescent response indicating the oxidation of hydroxyl. The flexible Phenol fluorophores are allowed to prepare multiple fluorescent probes towards H2O2 or ONOO− for environmental and physiological applications.
中文翻译：
基于茜素的分子探针，用于检测过氧化氢和过氧亚硝酸盐
酚荧光团是一大类荧光团，在探针设计中已引起越来越多的关注。利用芳烃硼酸与茜素红S（ARS）和加仑蛋白（GAL）的自组装，为过氧化氢（H 2 O 2）提供了新型化学传感器ARS–CBA和GAL–CBA ，证明了它们的检测能力。 H 2 O 2通过比色法和电化学测量进行指示剂位移测定（IDA）。ARS–CBA和GAL–CBA与H 2 O 2反应后，该系统在水性介质中显示出红移的可见颜色变化，并且关闭的电化学信号显示苯酚的产生。化学传感器ARS–CBA在荧光测量中也具有良好的性能，并且关闭的荧光响应表明已去除了芳香族硼酸。此外，所设计的近红外（NIR）双态荧光探针茜素蓝S（ABS）用于过氧亚硝酸盐（ONOO - ），在二甲亚砜（DMSO）的可见光比色变化和“开-关”，表示荧光响应羟基的氧化。柔性酚荧光团被允许朝ħ准备多个荧光探针2 ö 2或ONOO -在环境和生理用途。
更新日期：2020-12-09
中文翻译：
基于茜素的分子探针，用于检测过氧化氢和过氧亚硝酸盐
酚荧光团是一大类荧光团，在探针设计中已引起越来越多的关注。利用芳烃硼酸与茜素红S（ARS）和加仑蛋白（GAL）的自组装，为过氧化氢（H 2 O 2）提供了新型化学传感器ARS–CBA和GAL–CBA ，证明了它们的检测能力。 H 2 O 2通过比色法和电化学测量进行指示剂位移测定（IDA）。ARS–CBA和GAL–CBA与H 2 O 2反应后，该系统在水性介质中显示出红移的可见颜色变化，并且关闭的电化学信号显示苯酚的产生。化学传感器ARS–CBA在荧光测量中也具有良好的性能，并且关闭的荧光响应表明已去除了芳香族硼酸。此外，所设计的近红外（NIR）双态荧光探针茜素蓝S（ABS）用于过氧亚硝酸盐（ONOO - ），在二甲亚砜（DMSO）的可见光比色变化和“开-关”，表示荧光响应羟基的氧化。柔性酚荧光团被允许朝ħ准备多个荧光探针2 ö 2或ONOO -在环境和生理用途。
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