Human rhinoviruses have been linked both to the susceptibility of asthma development and to the triggering of acute exacerbations. Given that the human airway epithelial cell is the primary site of human rhinovirus (HRV) infection and replication, the current review focuses on how HRV-induced modulation of several aspects of epithelial cell phenotype could contribute to the development of asthma or to the induction of exacerbations. Modification of epithelial proinflammatory and antiviral responses are considered, as are alterations in an epithelial barrier function and cell phenotype. The contributions of the epithelium to airway remodeling and to the potential modulation of immune responses are also considered. The potential interactions of each type of HRV-induced epithelial phenotypic changes with allergic sensitization and allergic phenotype are also considered in the context of asthma development and of acute exacerbations.

中文翻译：

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鼻病毒诱导的上皮表型调节：在哮喘中的作用。

人类鼻病毒与哮喘发展的易感性和急性加重的触发都有联系。鉴于人气道上皮细胞是人鼻病毒（HRV）感染和复制的主要部位，本综述着重于HRV诱导的上皮细胞表型几个方面的调节如何促进哮喘的发展或对哮喘的诱导。恶化。考虑到上皮促炎和抗病毒反应的改变，以及上皮屏障功能和细胞表型的改变。还考虑了上皮对气道重塑和免疫应答的潜在调节的贡献。